Ju, Soomi Lee, Ki-Young Min, Sun-Joon Yoo, Yong Kyoung Hwang, Kyo Seon Kim, Sang Kyung Yi, Hyunjung 2024-01-20T07:32:11Z 2024-01-20T07:32:11Z 2021-09-04 2015-03-17 2045-2322 https://pubs.kist.re.kr/handle/201004/125660 Although volatile organic compounds (VOCs) are becoming increasingly recognized as harmful agents and potential biomarkers, selective detection of the organic targets remains a tremendous challenge. Among the materials being investigated for target recognition, peptides are attractive candidates because of their chemical robustness, divergence, and their homology to natural olfactory receptors. Using a combinatorial peptide library and either a graphitic surface or phenyl-terminated self-assembled monolayer as relevant target surfaces, we successfully selected three interesting peptides that differentiate a single carbon deviation among benzene and its analogues. The heterogeneity of the designed target surfaces provided peptides with varying affinity toward targeted molecules and generated a set of selective peptides that complemented each other. Microcantilever sensors conjugated with each peptide quantitated benzene, toluene and xylene to sub-ppm levels in real time. The selection of specific receptors for a group of volatile molecules will provide a strong foundation for general approach to individually monitoring VOCs. English NATURE PUBLISHING GROUP PULMONARY-DISEASES SENSOR BIOMARKERS BENZENE MICROCANTILEVER NANOSTRUCTURES EXPLOSIVES LEUKEMIA BINDING Single-carbon discrimination by selected peptides for individual detection of volatile organic compounds Article 10.1038/srep09196 1 SCIENTIFIC REPORTS, v.5 SCIENTIFIC REPORTS 5 scie scopus 000351230000007 2-s2.0-84924942348 Multidisciplinary Sciences Science & Technology - Other Topics Article PULMONARY-DISEASES SENSOR BIOMARKERS BENZENE MICROCANTILEVER NANOSTRUCTURES EXPLOSIVES LEUKEMIA BINDING