Kim, Hyungmin Park, Michael Y. Lee, Stephanie D. Lee, Wonhye Chiu, Alan Yoo, Seung-Schik 2024-01-20T07:32:22Z 2024-01-20T07:32:22Z 2021-09-05 2015-03 0959-4965 https://pubs.kist.re.kr/handle/201004/125670 We investigated the use of pulsed low-intensity focused ultrasound (FUS) to suppress the visual neural response induced by light stimulation in rodents. FUS was administered transcranially to the rat visual cortex using different acoustic intensities and pulsing duty cycles. The visual-evoked potentials (VEPs) generated by an external strobe light stimulation were measured three times before, once during, and five times after the sonication. The VEP magnitude was suppressed during the sonication using a 5% duty cycle (pulse-repetition frequency of 100 Hz) and a spatial-peak pulse-average acoustic intensity of 3W/cm(2); however, this suppressive effect was not present when a lower acoustic intensity and duty cycle were used. The application of a higher intensity and duty cycle resulted in a slight elevation in VEP magnitude, which suggested excitatory neuromodulation. Our findings demonstrate that the application of pulsed FUS to the region-specific brain area not only suppresses its excitability, but can also enhance the excitability depending on the acoustic intensity and the rate of energy deposition. This bimodal feature of FUS-mediated neuromodulation, which has been predicted by numerical models on neural membrane capacitance change by the external acoustic pressure waves, suggests its versatility for neurotherapeutic applications. Copyright (C) 2015 Wolters Kluwer Health, Inc. All rights reserved. English LIPPINCOTT WILLIAMS & WILKINS Suppression of EEG visual-evoked potentials in rats through neuromodulatory focused ultrasound Article 10.1097/WNR.0000000000000330 1 NeuroReport, v.26, no.4, pp.211 - 215 NeuroReport 26 4 211 215 N scie scopus 000349801500006 2-s2.0-84923643508 Neurosciences Neurosciences & Neurology Article NONINVASIVE BRAIN-STIMULATION PARAMETERS EEG focused ultrasound neuromodulation neurotherapeutics suppression ultrasound