Verma, Pushpa Augustine, George J. Ammar, Mohamed-Raafet Tashiro, Ayumu Cohen, Stephen M. 2024-01-20T07:32:35Z 2024-01-20T07:32:35Z 2022-01-25 2015-03 1097-6256 https://pubs.kist.re.kr/handle/201004/125681 Evidence has begun to emerge for microRNAs as regulators of synaptic signaling, specifically acting to control postsynaptic responsiveness during synaptic transmission. In this report, we provide evidence that Drosophila melanogaster miR-1000 acts presynaptically to regulate glutamate release at the synapse by controlling expression of the vesicular glutamate transporter (VGIut). Genetic deletion of miR-1000 led to elevated apoptosis in the brain as a result of glutamatergic excitotoxicity. The seed-similar miR-137 regulated VGIuT2 expression in mouse neurons. These conserved miRNAs share a neuroprotective function in the brains of flies and mice. Drosophila miR-1000 showed activity-dependent expression, which might serve as a mechanism to allow neuronal activity to fine-tune the strength of excitatory synaptic transmission. English NATURE PUBLISHING GROUP A neuroprotective role for microRNA miR-1000 mediated by limiting glutamate excitotoxicity Article 10.1038/nn.3935 1 NATURE NEUROSCIENCE, v.18, no.3, pp.379 - 385 NATURE NEUROSCIENCE 18 3 379 385 N scie scopus 000350195100017 2-s2.0-84923763986 Neurosciences Neurosciences & Neurology Article SPORADIC ALZHEIMERS-DISEASE PARKINSONS-DISEASE UBIQUITIN LIGASE EXPRESSION DROSOPHILA NEURODEGENERATION TRANSPORTER METHAMPHETAMINE SYNAPSES ELEGANS