Lee, Jiyeon Hwang, Gyoyeon Hong, Yeon Sun Sim, Taebo 2024-01-20T07:32:51Z 2024-01-20T07:32:51Z 2021-09-05 2015-03 0003-2654 https://pubs.kist.re.kr/handle/201004/125694 Dual modal nanoprobes are promising tools for accurately detecting target molecules as part of the diagnosis of diseases including cancers. We have explored a new dual modal bioimaging probe that is comprised of a quantum dot (QD)-magnetic nanoparticle (MNP) hybrid. The MNP-QD heterodimers explored are fabricated by using a platinum-guanine coordination bonding guided self-assembly process, employing the metal-DNA conjugation method. Investigations utilizing energy dispersive spectroscopy (EDS) equipped high resolution transmission electron microscopy (HRTEM) demonstrate that the heterodimer contains an iron (Fe) dominant MNP and a cadmium (Cd) dominant QD. Finally, the results of cell studies show that the MNP-QD conjugates display good HeLa cell uptake in the absence of non-specific binding to the cell membrane and, as such, they can be used to label cells in vitro and in vivo as part of a new cell imaging technique. English Royal Society of Chemistry DELIVERY PROBES SYSTEM OXIDE One step synthesis of quantum dot-magnetic nanoparticle heterodimers for dual modal imaging applications Article 10.1039/c4an02322f 1 Analyst, v.140, no.8, pp.2864 - 2868 Analyst 140 8 2864 2868 scie scopus 000352141800042 2-s2.0-84952877494 Chemistry, Analytical Chemistry Article DELIVERY PROBES SYSTEM OXIDE