Kim, Youngjae Kim, Minjoo Park, Mooseong Tae, Jinsung Baek, Du-Jong Park, Ki Duk Choo, Hyunah 2024-01-20T07:33:09Z 2024-01-20T07:33:09Z 2021-09-05 2015-03 1420-3049 https://pubs.kist.re.kr/handle/201004/125711 A novel molecular scaffold, dihydropyridothienopyrimidin-4,9-dione, was synthesized from benzylamine or p-methoxybenzylamine in six steps involving successive ring closure to form a fused ring system composed of dihydropyridone, thiophene and pyrimidone. The pharmacological versatility of the dihydropyridothenopyrimidin-4,9-dione scaffold was demonstrated by inhibitory activity against metabotropic glutamate receptor subtype 1 (mGluR1), which shows that the title compounds can serve as an interesting scaffold for the discovery of potential bioactive molecules for the treatment of human diseases. English MDPI AG MGLUR1 ANTAGONISTS CLOPIDOGREL PAIN Synthesis of Novel Dihydropyridothienopyrimidin-4,9-dione Derivatives Article 10.3390/molecules20035074 1 MOLECULES, v.20, no.3, pp.5074 - 5084 MOLECULES 20 3 5074 5084 scie scopus 000352472000055 2-s2.0-84929603562 Biochemistry & Molecular Biology Chemistry, Multidisciplinary Biochemistry & Molecular Biology Chemistry Article MGLUR1 ANTAGONISTS CLOPIDOGREL PAIN Dihydropyridothienopyrimidin-4,9-dione Pyridothienopyrimidine Successive ring formation