Cho, Chang-Hoon Lee, Young-Sun Kim, Eunju Hwang, Eun Mi Park, Jae-Yong 2024-01-20T08:00:59Z 2024-01-20T08:00:59Z 2021-09-05 2015-01-31 1976-6696 https://pubs.kist.re.kr/handle/201004/125845 Transient Receptor Potential, Melastatin-related, member 4 (TRPM4) channels are Ca2+-activated Ca2+-impermeable cation channels. These channels are expressed in various types of mammalian tissues including the brain and are implicated in many diverse physiological and pathophysiological conditions. In the past several years, the trafficking processes and regulatory mechanism of these channels and their interacting proteins have been uncovered. Here in this minireview, we summarize the current understanding of the trafficking mechanism of TRPM4 channels on the plasma membrane as well as heteromeric complex formation via protein interactions. We also describe physiological implications of protein-TRPM4 interactions and suggest TRPM4 channels as therapeutic targets in many related diseases. English KOREAN SOCIETY BIOCHEMISTRY & MOLECULAR BIOLOGY GATED ION CHANNELS NEUROTRANSMITTER RECEPTORS GLYCOSYLATION TRAFFICKING MELASTATIN PHOSPHORYLATION MODULATION EXPRESSION NEURONS CELLS Physiological functions of the TRPM4 channels via protein interactions Article 10.5483/BMBRep.2015.48.1.252 1 BMB REPORTS, v.48, no.1, pp.1 - 5 BMB REPORTS 48 1 1 5 scie scopus kci 000351719600001 2-s2.0-84922324783 Biochemistry & Molecular Biology Biochemistry & Molecular Biology Review GATED ION CHANNELS NEUROTRANSMITTER RECEPTORS GLYCOSYLATION TRAFFICKING MELASTATIN PHOSPHORYLATION MODULATION EXPRESSION NEURONS CELLS Glycosylation Heteromerization Phosphorylation SUMOylation Trafficking TRPM4 14-3-gamma