El-Din, Mahmoud M. Gamal El-Gamal, Mohammed I. Abdel-Maksoud, Mohammed S. Yoo, Kyung Ho Oh, Chang-Hyun 2024-01-20T08:01:04Z 2024-01-20T08:01:04Z 2022-01-10 2015-01-27 0223-5234 https://pubs.kist.re.kr/handle/201004/125848 Synthesis of a new series of 1,3,4-oxadiazole derivatives possessing sulfonamide moiety is described. Their in vitro antiproliferative activities against NCI-58 human cancer cell lines of nine different cancer types were tested. Compound 1k with p-methoxybenzenesulfonamido moiety showed the highest mean %inhibition value over the 58 cell line panel at 10 mu M concentration. It showed broad-spectrum antiproliferative activity over many cell lines of different cancer types. For instance, compound 1k inhibited the growth of T-47D breast cancer cell line by 90.47% at 10 mu M. And it inhibited growth of SR leukemia, SK-MEL-5 melanoma, and MDA-MB-468 breast cancer cell lines by more than 80% at the same test concentration. Compound 1k showed superior activity than Paditaxel and Gefitinib against the most sensitive cell lines. (C) 2014 Elsevier Masson SAS. All rights reserved. English ELSEVIER FRANCE-EDITIONS SCIENTIFIQUES MEDICALES ELSEVIER BIOLOGICAL EVALUATION ANTICANCER ACTIVITY BEARING OXADIAZOLE DESIGN AGENTS INHIBITORS CANCER NUCLEUS SERIES ACID Synthesis and in vitro antiproliferative activity of new 1,3,4-oxadiazole derivatives possessing sulfonamide moiety Article 10.1016/j.ejmech.2014.11.011 1 EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, v.90, pp.45 - 52 EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY 90 45 52 scie scopus 000348951900005 2-s2.0-84910110586 Chemistry, Medicinal Pharmacology & Pharmacy Article BIOLOGICAL EVALUATION ANTICANCER ACTIVITY BEARING OXADIAZOLE DESIGN AGENTS INHIBITORS CANCER NUCLEUS SERIES ACID Antiproliferative activity 1,3,4-Oxadiazole Sulfonamide