Park, Young-Gyun Choi, Jee Hyun Lee, Chungki Kim, Sehyun Kim, Youngsoo Chang, Ki-Young Paek, Sun Ha Kim, Daesoo 2024-01-20T08:01:23Z 2024-01-20T08:01:23Z 2021-09-05 2015-01-15 1756-6606 https://pubs.kist.re.kr/handle/201004/125865 Background: Identifying a neural circuit mechanism that is differentially involved in tremor would aid in the diagnosis and cure of such cases. Here, we demonstrate that tremor-related cortical potential (TRCP) is differentially expressed in two different mouse models of tremor. Results: Hybrid tremor analysis of harmaline-induced and genetic tremor in mice revealed that two authentic tremor frequencies for each type of tremor were conserved and showed an opposite dependence on CaV3.1 T-type Ca2+ channels. Electroencephalogram recordings revealed that a1(-/-); a1G(-/-) mice double-null for the GABA receptor a1 subunit (Gabra1) and CaV3.1 T-type Ca2+ channels (Cacna1g), in which the tremor caused by the absence of Gabra1 is potentiated by the absence of Cacna1g, showed a coherent TRCP that exhibited an onset that preceded the initiation of behavioral tremor by 3 ms. However, harmaline-induced tremor, which is known to be abolished by a1G(-/-), showed no TRCP. Conclusions: Our results demonstrate that the a1(-/-); a1G(-/-) double-knockout tremor model is useful for studying cortical mechanisms of tremor. English BMC HARMALINE-INDUCED TREMOR CHANNELS CA(V)3.1 Heterogeneity of tremor mechanisms assessed by tremor-related cortical potential in mice Article 10.1186/s13041-015-0093-2 1 MOLECULAR BRAIN, v.8 MOLECULAR BRAIN 8 scie scopus 000348233900001 Neurosciences Neurosciences & Neurology Article HARMALINE-INDUCED TREMOR CHANNELS CA(V)3.1 Tremor mechanism Cortical rhythm Harmaline T-type Ca2+ channels