Kim, Dongwook Hwang, Eunjin Lee, Mina Sung, Hokun Choi, Jee Hyun 2024-01-20T08:01:42Z 2024-01-20T08:01:42Z 2021-09-05 2015-01-01 0161-8105 https://pubs.kist.re.kr/handle/201004/125880 Study Objective: Sleep spindles in humans have been classified as slow anterior and fast posterior spindles; recent findings indicate that their profiles differ according to pharmacology, pathology, and function. However, little is known about the generation mechanisms within the thalamocortical system for different types of spindles. In this study, we aim to investigate the electrophysiological behaviors of the topographically distinctive spindles within the thalamocortical system by applying high-density EEG and simultaneous thalamic LFP recordings in mice. Design: 32-channel extracranial EEG and 2-channel thalamic LFP were recorded simultaneously in freely behaving mice to acquire spindles during spontaneous sleep. Subjects: Hybrid F1 male mice of C57BL/6J and 129S4/svJae. Measurements and Results: Spindle events in each channel were detected by spindle detection algorithm, and then a cluster analysis was applied to classify the topographically distinctive spindles. All sleep spindles were successfully classified into 3 groups: anterior, posterior, and global spindles. Each spindle type showed distinct thalamocortical activity patterns regarding the extent of similarity, phase synchrony, and time lags between cortical and thalamic areas during spindle oscillation. We also found that sleep slow waves were likely to associate with all types of sleep spindles, but also that the ongoing cortical decruitment/recruitment dynamics before the onset of spindles and their relationship with spindle generation were also variable, depending on the spindle types. Conclusion: Topographically specific sleep spindles show distinctive thalamocortical network behaviors. English OXFORD UNIV PRESS INC SLOW WAVES CORTICAL SYNCHRONIZATION RETICULAR NUCLEUS CINGULATE CORTEX HIGH-RESOLUTION K-COMPLEX EEG OSCILLATION CIRCUITRY BRAIN Characterization of Topographically Specific Sleep Spindles in Mice Article 10.5665/sleep.4330 1 SLEEP, v.38, no.1, pp.85 - 96 SLEEP 38 1 85 96 scie scopus 000347169300011 2-s2.0-84920494750 Clinical Neurology Neurosciences Neurosciences & Neurology Article SLOW WAVES CORTICAL SYNCHRONIZATION RETICULAR NUCLEUS CINGULATE CORTEX HIGH-RESOLUTION K-COMPLEX EEG OSCILLATION CIRCUITRY BRAIN sleep spindles high-density EEG thalamic LFP thalamocortical networks topography sleep slow waves mouse