Kim, Taejung Kim, Young-Joo Han, Im-Ho Lee, Dahae Ham, Jungyeob Kang, Ki Sung Lee, Jae Wook 2024-01-20T08:01:43Z 2024-01-20T08:01:43Z 2021-09-05 2015-01-01 0960-894X https://pubs.kist.re.kr/handle/201004/125881 A series of sulforaphane analogues were synthesized with various amines by treatment of carbon disulfide followed by Boc(2)O and DMAP. These synthesized sulforaphane analogues were tested on cisplatin treated cultured LLC-PK1 kidney cell line. Among these analogues, several compounds including SF5 show a potent effect on kidney cell protection assay at the concentration of 2.5 mu M. Further studies with compound SF5 revealed that the kidney cell protection effect was related by inhibiting the apoptosis pathway through JNK-p53-caspase apoptotic cascade. Compound SF5 may be considered as a promising candidate for the development of new kidney protection agent against drug induced acute kidney disease. (C) 2014 Elsevier Ltd. All rights reserved. English Pergamon Press Ltd. INDUCED APOPTOSIS IN-VITRO MOLECULAR-BASIS LLC-PK1 CELLS DNA-DAMAGE ACTIVATION INDUCTION MOUSE P53 CHEMOPREVENTION The synthesis of sulforaphane analogues and their protection effect against cisplatin induced cytotoxicity in kidney cells Article 10.1016/j.bmcl.2014.11.014 1 Bioorganic & Medicinal Chemistry Letters, v.25, no.1, pp.62 - 66 Bioorganic & Medicinal Chemistry Letters 25 1 62 66 scie scopus 000345581600012 2-s2.0-84913534815 Chemistry, Medicinal Chemistry, Organic Pharmacology & Pharmacy Chemistry Article INDUCED APOPTOSIS IN-VITRO MOLECULAR-BASIS LLC-PK1 CELLS DNA-DAMAGE ACTIVATION INDUCTION MOUSE P53 CHEMOPREVENTION Sulforaphane Cisplatin induced kidney disease Kidney protection Reactive oxygen species Isothiocyanate