Seo, Young Hun Cho, Mm Ju Cheong, Oug Jae Jang, Woo-Dong Ohulchanskyy, Tymish Y. Lee, Sangyoup Choi, Dong Hoon Prasad, Paras N. Kim, Sehoon 2024-01-20T08:02:24Z 2024-01-20T08:02:24Z 2021-09-05 2015-01 0142-9612 https://pubs.kist.re.kr/handle/201004/125916 Photonic nanomaterials have found wide applications in theranostics. We introduce here a design of allorganic photonic nanoparticles, different from traditional ones, in which we utilize nanoblend of a low-bandgap pi-conjugated polymer (LB-CP) and polystyrene as the photonic core, surrounded by an FDA-approved polymeric surfactant. This design provides capability for efficient deep tissue imaging using highly penetrating near-infrared (NIR) excitation and emission of LB-CP and also allows us to incorporate a NIR phosphorescent oxygen-sensitive dye in the core to serve as a dual-emissive probe for hypoxia imaging. These biophotonic nanoblend (BNB) particles (similar to 20 nm in diameter) show facile blood circulation, efficient disease targeting and minimal liver filtration as well as sustained renal excretion in the intravenously administered mouse models, as noninvasively visualized by the NIR emission signals. In diseased mouse models, pathological tissue deoxygenation at hypoxic sites was successfully detected with ratiometric spectral information. We also show that our nanoformulation exhibits no apparent toxicity, thus serving as a versatile biophotonics platform for diagnostic imaging. (C) 2014 Elsevier Ltd. All rights reserved. English ELSEVIER SCI LTD POLYMER NANOPARTICLES HYPOXIA FLUORESCENCE DOTS Low-bandgap biophotonic nanoblend: A platform for systemic disease targeting and functional imaging Article 10.1016/j.biomaterials.2014.10.074 1 BIOMATERIALS, v.39, pp.225 - 233 BIOMATERIALS 39 225 233 scie scopus 000347760600024 2-s2.0-84919498421 Engineering, Biomedical Materials Science, Biomaterials Engineering Materials Science Article POLYMER NANOPARTICLES HYPOXIA FLUORESCENCE DOTS Biosensors Hypoxia Imaging agents Low-bandgap conjugated polymers Nanoparticles