Han, Hyung-Seop Lee, Sun Hee Kim, Won-Joo Jeon, Hojeong Seok, Hyun-Kwang Ahn, Jae-Pyung Kim, Yu-Chan 2024-01-20T08:02:55Z 2024-01-20T08:02:55Z 2021-09-05 2015-01 1598-9623 https://pubs.kist.re.kr/handle/201004/125945 In this study, the surface modification of biodegradable pure Magnesium and Mg-5wt%Ca-1 wt%Zn alloy was performed through immersion in HBSS, inorganic salt solution and cell media to reduce initial hydrogen evolution and improve cell adhesion. The formation of different CaP-like coatings from immersion of pure Mg and Mg alloy were observed using Cryo FM analysis and their performances were measured through cell adhesion, quantification of released Mg ions, and cell cytotoxicity assays. The coating layers displayed significant reduction of initial corrosion rate, and cell adhesion for both pure Mg and Mg alloy appeared to be influenced by the amino acids and proteins in the cell media. In general, Mg alloy showed a denser coating layer with higher Ca contents, resulting in greater reduction of initial corrosion rate and improved cell adhesion, when compared to pure Mg. This is due to saturation of Ca around the corrosion site that provided much favorable environmental condition to produce denser calcium phosphate coating mixture. The result from this study suggests that the surface modification of biodegradable Mg alloy by immersion in alkaline solutions can be utilized to obtain ideal biodegradable orthopedic implant material with reduced initial hydrogen evolution rate and improved cell adhesion. English 대한금속·재료학회 Reduction of Initial Corrosion Rate and Improvement of Cell Adhesion Through Surface Modification of Biodegradable Mg Alloy Article 10.1007/s12540-015-1024-6 1 Metals and Materials International, v.21, no.1, pp.194 - 201 Metals and Materials International 21 1 194 201 N scie scopus kci ART001950721 000348245300024 2-s2.0-84921724974 Materials Science, Multidisciplinary Metallurgy & Metallurgical Engineering Materials Science Metallurgy & Metallurgical Engineering Article PURE MAGNESIUM ORTHOPEDIC IMPLANTS AMINO-ACIDS IN-VITRO DEGRADATION TITANIUM SUSCEPTIBILITY BIOMATERIAL BEHAVIOR BONE biomaterials metals alloys surface modification corrosion focused ion beam