Kim, Seyeon Kim, Eunae Oh, Chang-Hyun Yoo, Kyung Ho Hong, Joon Hee 2024-01-20T08:03:36Z 2024-01-20T08:03:36Z 2021-09-05 2014-12-20 0253-2964 https://pubs.kist.re.kr/handle/201004/125980 The first synthetic route to 5'-norcarbocyclic C-nucleoside [7-oxa-7,9-dideazadenosine (furo[3,2-d]pyrimidine) and 9-deazaadenosine (pyrrolo[3,2-d]pyrimidine)] phosphonic acids from commercially available 1,3dihydroxy cyclopentane was described. The key C-C bond formation from sugar to base precursor was performed using Knoevenagel-type condensation from a ketone derivative. Synthesized C-nucleoside phosphonic acids were tested for anti-HIV activity as well as anti-leukemic activity. Compound 26 showed significant anti-leukemic activity. English WILEY-V C H VERLAG GMBH ENANTIOSELECTIVE SYNTHESIS ANTIVIRAL ACTIVITY NUCLEOTIDE ANALOGS FACILE SYNTHESIS ADENOSINE Synthesis and Potent Anti-leukemic Activity of Novel 5 '-Norcarbocyclic C-nucleoside Phosphonic Acids Article 10.5012/bkcs.2014.35.12.3502 1 BULLETIN OF THE KOREAN CHEMICAL SOCIETY, v.35, no.12, pp.3502 - 3508 BULLETIN OF THE KOREAN CHEMICAL SOCIETY 35 12 3502 3508 scie scopus kci ART001932306 000346113000017 2-s2.0-84920067251 Chemistry, Multidisciplinary Chemistry Article ENANTIOSELECTIVE SYNTHESIS ANTIVIRAL ACTIVITY NUCLEOTIDE ANALOGS FACILE SYNTHESIS ADENOSINE Antiviral agent Anti-leukemic agent C-nucleoside Knoevenagel reaction