Kim, Hye Yun Kim, Hyunjin V. Yoon, Jin H. Kang, Bo Ram Cho, Soo Min Lee, Sejin Kim, Ji Yoon Kim, Joo Won Cho, Yakdol Woo, Jiwan Kim, YoungSoo 2024-01-20T08:03:52Z 2024-01-20T08:03:52Z 2022-01-10 2014-12-12 2045-2322 https://pubs.kist.re.kr/handle/201004/125993 Alzheimer's disease (AD) is a lethal progressive neurological disorder affecting the memory. Recently, US Food and Drug Administration mitigated the standard for drug approval, allowing symptomatic drugs that only improve cognitive deficits to be allowed to accelerate on to clinical trials. Our study focuses on taurine, an endogenous amino acid found in high concentrations in humans. It has demonstrated neuroprotective properties against many forms of dementia. In this study, we assessed cognitively enhancing property of taurine in transgenic mouse model of AD. We orally administered taurine via drinking water to adult APP/PS1 transgenic mouse model for 6 weeks. Taurine treatment rescued cognitive deficits in APP/PS1 mice up to the age-matching wild-type mice in Y-maze and passive avoidance tests without modifying the behaviours of cognitively normal mice. In the cortex of APP/PS1 mice, taurine slightly decreased insoluble fraction of A beta. While the exact mechanism of taurine in AD has not yet been ascertained, our results suggest that taurine can aid cognitive impairment and may inhibit A beta-related damages. English NATURE PUBLISHING GROUP CONGESTIVE-HEART-FAILURE REACTIVE ASTROCYTES RECEPTORS SUPPLEMENTATION NEUROTOXICITY AGGREGATION ACTIVATION HYPOXIA NEURONS BRAIN Taurine in drinking water recovers learning and memory in the adult APP/PS1 mouse model of Alzheimer's disease Article 10.1038/srep07467 1 SCIENTIFIC REPORTS, v.4 SCIENTIFIC REPORTS 4 scie scopus 000346300600006 2-s2.0-84927610131 Multidisciplinary Sciences Science & Technology - Other Topics Article CONGESTIVE-HEART-FAILURE REACTIVE ASTROCYTES RECEPTORS SUPPLEMENTATION NEUROTOXICITY AGGREGATION ACTIVATION HYPOXIA NEURONS BRAIN