Jeong, Yoon Choi, Jonghoon Lee, Kwan Hyi 2024-01-20T08:04:12Z 2024-01-20T08:04:12Z 2021-09-02 2014-12-01 1937-3368 https://pubs.kist.re.kr/handle/201004/126011 Scientists have endeavored to use stem cells for a variety of applications ranging from basic science research to translational medicine. Population-based characterization of such stem cells, while providing an important foundation to further development, often disregard the heterogeneity inherent among individual constituents within a given population. The population-based analysis and characterization of stem cells and the problems associated with such a blanket approach only underscore the need for the development of new analytical technology. In this article, we review current stem cell analytical technologies, along with the advantages and disadvantages of each, followed by applications of these technologies in the field of stem cells. Furthermore, while recent advances in micro/nano technology have led to a growth in the stem cell analytical field, underlying architectural concepts allow only for a vertical analytical approach, in which different desirable parameters are obtained from multiple individual experiments and there are many technical challenges that limit vertically integrated analytical tools. Therefore, we propose-by introducing a concept of vertical and horizontal approach-that there is the need of adequate methods to the integration of information, such that multiple descriptive parameters from a stem cell can be obtained from a single experiment. English MARY ANN LIEBERT, INC HIGH-THROUGHPUT ANALYSIS ON-A-CHIP NATURAL-KILLER-CELLS SINGLE-CELLS IN-VIVO INDUCED PLURIPOTENT SELF-RENEWAL MICROFLUIDIC DEVICE EXTRACELLULAR-MATRIX MICROWELL ARRAYS Technology Advancement for Integrative Stem Cell Analyses Article 10.1089/ten.teb.2014.0141 1 TISSUE ENGINEERING PART B-REVIEWS, v.20, no.6, pp.669 - 682 TISSUE ENGINEERING PART B-REVIEWS 20 6 669 682 scie scopus 000345205200009 2-s2.0-84913594092 Cell & Tissue Engineering Biotechnology & Applied Microbiology Cell Biology Engineering, Biomedical Materials Science, Biomaterials Cell Biology Biotechnology & Applied Microbiology Engineering Materials Science Review HIGH-THROUGHPUT ANALYSIS ON-A-CHIP NATURAL-KILLER-CELLS SINGLE-CELLS IN-VIVO INDUCED PLURIPOTENT SELF-RENEWAL MICROFLUIDIC DEVICE EXTRACELLULAR-MATRIX MICROWELL ARRAYS Stem Cell Integrative Analysis Technology Advancement