Lee, Heon-Myung Rim, Hong-Kun Seo, Jong-Hwan Kook, Yoon-Bum Kim, Sung-Kew Oh, Chang-Hyun Yoo, Kyung Ho Jin, Jong-Sik An, Hyo-Jin 2024-01-20T08:04:19Z 2024-01-20T08:04:19Z 2022-01-25 2014-12 1472-6882 https://pubs.kist.re.kr/handle/201004/126018 Background: HOX-7 is a newly developed dietary formula composed of traditional oriental herbal medicines. The formula was developed with the aim of improving weight control. We investigated the anti-obesity effect of HOX-7 on high-fat-diet (HFD)-induced obesity in C57BL/6 mice. Methods: The mice were divided into four groups and were fed a normal diet (ND), HFD, or HFD with oral administration of HOX-7 at 100 or 200 mg/kg/day for 12 weeks. Body and fat weight, histological changes of fat tissue, and the expression of key adipogenic transcription factors were investigated. Results: The body weight of mice fed the HFD with HOX-7 was significantly decreased compared to the HFD group. There were no obvious differences in weekly food intake among the 4 groups. The weight of the epididymal and total fat pads was reduced in mice fed the HFD with HOX-7. Treatment with HOX-7 also substantially attenuated the expression of key adipogenic transcription factors, including peroxisome proliferatoractivated receptor., CCAAT/enhancer binding protein a, sterol regulatory element binding protein 1c, adipocyte P2, liver X receptor, and lipoprotein lipase in the epididymal adipose tissue. Conclusion: Overall, this study highlighted the anti-obesity effects of HOX-7, a finding that could contribute to the development of natural anti-obesity herbal medicines. English BIOMED CENTRAL LTD HOX-7 suppresses body weight gain and adipogenesis-related gene expression in high-fat-diet-induced obese mice Article 10.1186/1472-6882-14-505 1 BMC COMPLEMENTARY AND ALTERNATIVE MEDICINE, v.14 BMC COMPLEMENTARY AND ALTERNATIVE MEDICINE 14 N scie scopus 000348225000001 2-s2.0-84924288047 Integrative & Complementary Medicine Integrative & Complementary Medicine Article RECEPTOR-GAMMA EXPRESSION ADIPOCYTE DIFFERENTIATION SALICORNIA-HERBACEA ANTIOBESITY METABOLISM REGULATOR EXTRACT RATS C/EBPa Mice Obesity PPAR gamma SREBP1c Traditional herbal medicine