El-Gamal, Mohammed I. Khan, Mohammad Ashrafuddin Abdel-Maksoud, Mohammed S. El-Din, Mahmoud M. Gamal Oh, Chang-Hyun 2024-01-20T08:31:10Z 2024-01-20T08:31:10Z 2022-01-10 2014-11-24 0223-5234 https://pubs.kist.re.kr/handle/201004/126099 Synthesis of a new series of diarylamides possessing 6,7-dimethoxy(dihydroxy)quinoline scaffold is described. Their in vitro antiproliferative activities against NCI-58 human cancer cell lines of nine different cancer types were tested. Compounds 1a and 1d-g showed the highest mean %inhibition values oyer the 58 cell line panel at 10 mu M, and they were further tested in 5-dose testing mode to determine their IC50 values. The five compounds were more potent than Imatinib against all the cell lines of nine different cancer types. Compound 1g showed the highest potencies. It showed inhibitory effect against C-RAF kinase (76.65% at 10 mu M concentration). (C) 2014 Elsevier Masson SAS. All rights reserved. English ELSEVIER FRANCE-EDITIONS SCIENTIFIQUES MEDICALES ELSEVIER MELANOMA-CELL LINE PRELIMINARY CYTOTOXICITY EVALUATION ANTIPROLIFERATIVE ACTIVITY 1,3,4-TRIARYLPYRAZOLE SCAFFOLD BIOLOGICAL EVALUATION POTENTIAL ANTITUMOR LUNG CANCERS C-RAF DERIVATIVES DESIGN A new series of diarylamides possessing quinoline nucleus: Synthesis, in vitro anticancer activities, and kinase inhibitory effect Article 10.1016/j.ejmech.2014.09.068 1 EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, v.87, pp.484 - 492 EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY 87 484 492 scie scopus 000363431300045 2-s2.0-84949116139 Chemistry, Medicinal Pharmacology & Pharmacy Article MELANOMA-CELL LINE PRELIMINARY CYTOTOXICITY EVALUATION ANTIPROLIFERATIVE ACTIVITY 1,3,4-TRIARYLPYRAZOLE SCAFFOLD BIOLOGICAL EVALUATION POTENTIAL ANTITUMOR LUNG CANCERS C-RAF DERIVATIVES DESIGN Antiproliferative activity Diarylamide In silico C-RAF kinase Quinoline