Yhee, Ji Young Son, Sohee Kim, Sun Hwa Park, Kinam Choi, Kuiwon Kwon, Ick Chan 2024-01-20T08:31:41Z 2024-01-20T08:31:41Z 2021-09-02 2014-11-10 0168-3659 https://pubs.kist.re.kr/handle/201004/126125 Hydrophobically modified glycol chitosan (hGC) conjugates spontaneously form self-assembled nanoparticles (NPs) in aqueous conditions, and glycol chitosan NPs (CNPs) have been extensively studied for the past few decades. For disease-specific theranostics, CNPs could be simply modified with imaging agents, and the hydrophobic domains of hGC are available for encapsulation of various drugs. Based on the excellent physiochemical and biological properties, CNPs have been investigated for multimodal imaging and target specific drug delivery. In particular, a recent application of CNPs has shown great potential as an efficient theranostic system because the CNPs could be utilized for a disease-specific theranostic delivery system of different imaging agents and therapeutics, simultaneously. Furthermore, various therapeutic agents including chemo-drugs, nucleotides, peptides, and photodynamic chemicals could be simply encapsulated into the CNPs through hydrophobic or charge-charge interactions. Under in vivo conditions, the encapsulated imaging agents and therapeutic drugs have been successfully delivered to targeted diseases. In this article, the overall research progress on CNPs is reviewed from early works. The current challenges of CNPs to overcome in theranostics are also discussed, and continuous studies would provide more opportunities for early diagnosis of diseases and personalized medicine. (C) 2014 Elsevier B.V. All rights reserved. English ELSEVIER SCIENCE BV BEARING 5-BETA-CHOLANIC ACID TUMOR-TARGETING EFFICIENCY NONVIRAL GENE DELIVERY BLOOD-BRAIN-BARRIER IN-VIVO DRUG-DELIVERY POLYMERIC NANOPARTICLES PHOTODYNAMIC THERAPY CATHEPSIN-B CELLULAR UPTAKE Self-assembled glycol chitosan nanoparticles for disease-specific theranostics Article 10.1016/j.jconrel.2014.05.009 1 JOURNAL OF CONTROLLED RELEASE, v.193, pp.202 - 213 JOURNAL OF CONTROLLED RELEASE 193 202 213 scie scopus 000344229000019 2-s2.0-84908277949 Chemistry, Multidisciplinary Pharmacology & Pharmacy Chemistry Pharmacology & Pharmacy Article BEARING 5-BETA-CHOLANIC ACID TUMOR-TARGETING EFFICIENCY NONVIRAL GENE DELIVERY BLOOD-BRAIN-BARRIER IN-VIVO DRUG-DELIVERY POLYMERIC NANOPARTICLES PHOTODYNAMIC THERAPY CATHEPSIN-B CELLULAR UPTAKE Glycol chitosan Nanoparticles Targeted delivery Theranostics