Sun, Xiaoyan Kim, Yang-Hyun Trong Nhat Phan Yang, Beom-Seok 2024-01-20T08:31:59Z 2024-01-20T08:31:59Z 2022-01-10 2014-11-02 0916-8451 https://pubs.kist.re.kr/handle/201004/126140 Burn scar contracture that follows the healing of deep dermal burns causes severe deformation and functional impairment. However, its current therapeutic interventions are limited with unsatisfactory outcomes. When we treated deep second-degree burns in rat skin with activin-like kinase 5 (ALK5) inhibitor A-83-01, it reduced wound contraction and enhanced the area of re-epithelialization so that the overall time for wound closing was not altered. In addition, it reduced myofibroblast population in the dermis of burn scar with a diminished deposition of its biomarker proteins such as alpha-SMA and collagen. Treatment of rat dermal fibroblast with A-83-01 inhibited transforming growth factor-beta 1 (TGF-beta 1)-dependent induction of alpha-SMA and collagen type I. Taken together, these results suggest that topical application of ALK5 inhibitor A-83-01 could be effective in preventing the contraction of burn wound without delaying the wound closure by virtue of its inhibitory activity against the TGF-beta-induced increase of myofibroblast population. English TAYLOR & FRANCIS LTD GROWTH-FACTOR-BETA MUSCLE ACTIN EXPRESSION I-RECEPTOR KINASE TGF-BETA SIGNALING PATHWAY BREAST-CANCER TISSUE-REPAIR FIBROSIS CELLS LUNG Topical application of ALK5 inhibitor A-83-01 reduces burn wound contraction in rats by suppressing myofibroblast population Article 10.1080/09168451.2014.932666 1 BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY, v.78, no.11, pp.1805 - 1812 BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY 78 11 1805 1812 scie scopus 000343816500001 2-s2.0-84938524268 Biochemistry & Molecular Biology Biotechnology & Applied Microbiology Chemistry, Applied Food Science & Technology Biochemistry & Molecular Biology Biotechnology & Applied Microbiology Chemistry Food Science & Technology Article GROWTH-FACTOR-BETA MUSCLE ACTIN EXPRESSION I-RECEPTOR KINASE TGF-BETA SIGNALING PATHWAY BREAST-CANCER TISSUE-REPAIR FIBROSIS CELLS LUNG ALK5 inhibitor myofibroblast TGF-beta signaling A-83-01 burn wound contraction