Kim, Min Cheol Hwang, Eunson Kim, Taejung Ham, Jungyeob Kim, Sun Yeou Kwon, Hak Cheol 2024-01-20T08:34:56Z 2024-01-20T08:34:56Z 2021-09-02 2014-10 0163-3864 https://pubs.kist.re.kr/handle/201004/126292 Two new tetracenedione derivatives, nocatriones A (1) and B (2), were discovered from the culture broth of a marine actinomycete, Nocardiopsis sp. KMF-002, which was isolated from the tissue of an unidentified dark purple marine sponge. The structures of 1 and 2, which are tetracenediones containing a-pyrone substituents, were determined to be 3,8,10,11-tetrahydroxy-2-(4-hydroxy-2-oxo-2H-pyran-6-yl)-1-methyltetracene-5,12-dione (1) and 3,8,10,12-tetrahydroxy-2-(4-hydroxy-2-oxo-2H-pyran-6-yl)-1-methyltetracene-6,11-dione (2). Ultraviolet B (UVB)-irradiated cells treated with 10 mu M nocatrione A (1) significantly decreased the level of MMP-1, a protein that degrades collagen and other extracelluar matrix components that comprise dermal tissue, when compared to untreated cells. These results support that nocatriones A (1) and B (2) may show antiphotoaging activity in UVB-irradiated models. English AMER CHEMICAL SOC SKIN IRRADIATION MECHANISMS Nocatriones A and B, Photoprotective Tetracenediones from a Marine-Derived Nocardiopsis sp. Article 10.1021/np5006086 1 JOURNAL OF NATURAL PRODUCTS, v.77, no.10, pp.2326 - 2330 JOURNAL OF NATURAL PRODUCTS 77 10 2326 2330 scie scopus 000343786100023 2-s2.0-84908655218 Plant Sciences Chemistry, Medicinal Pharmacology & Pharmacy Plant Sciences Pharmacology & Pharmacy Article SKIN IRRADIATION MECHANISMS Marine Natural Products Marine Microorganism Nocardiopsis New compound Nocatrione Photoprotective antiphotoaging activity