Kim, Ji-young Alam, Farzana Chung, Seung Woo Park, Jooho Jeon, Ok Cheol Kim, Sang Yoon Son, Woo Chan Byun, Youngro 2024-01-20T09:00:29Z 2024-01-20T09:00:29Z 2021-09-02 2014-10 0959-4973 https://pubs.kist.re.kr/handle/201004/126312 To achieve a clinically rational regimen for cancer chemoprevention with improved efficacy and safety, the combination effect of celecoxib and newly developed oral angiogenesis inhibitor, LHD4, on chemoprevention was evaluated. The chemopreventive effects of celecoxib, LHD4, and the combination of celecoxib and LHD4 were evaluated in a murine colorectal carcinogenesis model. After 17 experimental weeks, mouse colon tissues were collected and examined in terms of polyp volume and degree of carcinogenesis, inflammation, and angiogenesis. Mice in the celecoxib-treated or LHD4-treated groups had total polyp volumes of 47.0 +/- 9.7 and 120.1 +/- 45.2mm(3), respectively, which represented decreases of 65.6 and 22.3% from the control (154.5 +/- 33.5mm(3)). However, the polyp volume in the combination group was 22.8 +/- 9.3mm(3), a decrease of 85.2% from the control. In the comparison of carcinogenesis, the percentage of normal tissue (i.e. excluding proliferative tissue) was found to be 40.6% in the control, 51.7% in the celecoxib, 56.9% in the LHD4, and 81.7% in the combination group. In accordance with attenuated carcinogenesis, both inflammation and angiogenesis were also well controlled. Together, these results suggest that the combinatory use of celecoxib and a newly developed oral heparin conjugate could be a promising regimen for chemoprevention by intervening in both inflammation and angiogenesis. Anti-Cancer Drugs 25: 1061-1071 (C) 2014 Wolters Kluwer Health vertical bar Lippincott Williams & Wilkins. English LIPPINCOTT WILLIAMS & WILKINS MOUSE COLON CARCINOGENESIS MOLECULAR-WEIGHT HEPARIN CANCER CHEMOPREVENTION DEOXYCHOLIC-ACID INTESTINAL CANCER GROWTH-FACTOR TUMOR-GROWTH ANGIOGENESIS INFLAMMATION PREVENTION Combinational chemoprevention effect of celecoxib and an oral antiangiogenic LHD4 on colorectal carcinogenesis in mice Article 10.1097/CAD.0000000000000141 1 ANTI-CANCER DRUGS, v.25, no.9, pp.1061 - 1071 ANTI-CANCER DRUGS 25 9 1061 1071 scie scopus 000341534700010 2-s2.0-85027923604 Oncology Pharmacology & Pharmacy Oncology Pharmacology & Pharmacy Article MOUSE COLON CARCINOGENESIS MOLECULAR-WEIGHT HEPARIN CANCER CHEMOPREVENTION DEOXYCHOLIC-ACID INTESTINAL CANCER GROWTH-FACTOR TUMOR-GROWTH ANGIOGENESIS INFLAMMATION PREVENTION angiogenesis celecoxib chemoprevention heparin conjugate inflammation