Jung, Ha-Wook Chang, Young Wook Lee, Ga-Yeon Cho, Sungbo Kang, Min-Jung Pyun, Jae-Chul 2024-01-20T09:00:55Z 2024-01-20T09:00:55Z 2021-09-02 2014-09-24 0003-2670 https://pubs.kist.re.kr/handle/201004/126332 A capacitive biosensor based on an interdigitated electrode (IDE) with nanoislands was developed for label-free detection of antigen-antibody interactions. To enable sensitive capacitive detection of protein adsorption, the nanoislands were fabricated between finger electrodes of the IDE. The effect of the nanoislands on the sensitive capacitive measurement was estimated using horseradish peroxidase (HRP) as a model protein. Additionally, a parylene-A film was coated on the IDE with nanoislands to improve the efficiency of protein immobilization. By using HRP and hepatitis B virus surface antigen (HBsAg) as model analytes, the effect of the parylene-A film on the capacitive detection of protein adsorption was demonstrated. (C) 2014 Elsevier B.V. All rights reserved. English ELSEVIER SENSITIVE DETECTION ESCHERICHIA-COLI IMMUNOSENSOR IMMOBILIZATION ANTIBODY ARRAYS A capacitive biosensor based on an interdigitated electrode with nanoislands Article 10.1016/j.aca.2014.07.006 1 ANALYTICA CHIMICA ACTA, v.844, pp.27 - 34 ANALYTICA CHIMICA ACTA 844 27 34 scie scopus 000341361200004 2-s2.0-84906933676 Chemistry, Analytical Chemistry Article SENSITIVE DETECTION ESCHERICHIA-COLI IMMUNOSENSOR IMMOBILIZATION ANTIBODY ARRAYS Interdigitated electrode Nanoisland Capacitive biosensor Hepatitis B virus Surface antigen Immunosensor