Kum, Chang Hun Cho, Youngjin Seo, Seong Ho Joung, Yoon Ki Ahn, Dong June Han, Dong Keun 2024-01-20T09:00:56Z 2024-01-20T09:00:56Z 2021-09-02 2014-09-24 1613-6810 https://pubs.kist.re.kr/handle/201004/126333 Biodegradable polymers such as poly(l-lactide) (PLLA) have been widely utilized as materials for biomedical applications. However, the relatively poor mechanical properties of PLLA and its acid-induced cell inflammation brought about by the acidic byproducts during biodegradation pose severe problems. In this study, these drawbacks of PLLA are addressed using a stereocomplex structure, where oligo-d-lactide-grafted magnesium hydroxide (MgO-ODLA) is synthesized by grafting d-lactide onto the surface of magnesium hydroxide, which is then blended with a PLLA film. The structure, morphology, pH change, thermal and mechanical properties, in-vitro cytotoxicity, and inflammation effect of the MgO-ODLAs and their PLLA composites are evaluated through various analyses. The PLLA/MgO70-ODLA30 (0-20 wt%) composite with a stereocomplex structure shows a 20% increase in its tensile strength and an improvement in the modulus compared to its oligo-l-lactide (PLLA/MgO70-OLLA30) counterpart. The interfacial interaction parameter of PLLA/MgO70-ODLA30 (5.459) has superior properties to those of PLLA/MgO70-OLLA30 (4.013) and PLLA/Mg(OH)(2) (1.774). The cell cytotoxicity and acid-induced inflammatory response are suppressed by the neutralizing effect of the MgO-ODLAs. In addition, the inflammatory problem caused by the rapid acidification of the stereocomplex structure is also addressed. As a result, the stereocomplex structure of the MgO-ODLA/PLLA composite can be used to overcome the problems associated with the biomedical applications of PLLA films. English WILEY-V C H VERLAG GMBH POLYLACTIDE DEGRADATION STENT BIOCOMPATIBILITY POLY(L-LACTIDE) COMPOSITES HYDROXIDE POLYMERS ALLOY FILMS A Poly(lactide) Stereocomplex Structure with Modified Magnesium Oxide and Its Effects in Enhancing the Mechanical Properties and Suppressing Inflammation Article 10.1002/smll.201302880 1 SMALL, v.10, no.18, pp.3783 - 3794 SMALL 10 18 3783 3794 scie scopus 000342687700026 2-s2.0-84941070221 Chemistry, Multidisciplinary Chemistry, Physical Nanoscience & Nanotechnology Materials Science, Multidisciplinary Physics, Applied Physics, Condensed Matter Chemistry Science & Technology - Other Topics Materials Science Physics Article POLYLACTIDE DEGRADATION STENT BIOCOMPATIBILITY POLY(L-LACTIDE) COMPOSITES HYDROXIDE POLYMERS ALLOY FILMS biomaterials bioinspired materials structure-property relationships polymers polylactide stereocomplex pH neutralization inflammation