El-Gamal, Mohammed I. Abdel-Maksoud, Mohammed S. El-Din, Mahmoud M. Gamal Yoo, Kyung Ho Baek, Daejin Oh, Chang-Hyun 2024-01-20T09:01:53Z 2024-01-20T09:01:53Z 2022-01-10 2014-09 0365-6233 https://pubs.kist.re.kr/handle/201004/126382 A bisamide compound 1 possessing the pyrrolo[3,2-c]pyridine nucleus was synthesized and biologically evaluated. It was tested for kinase inhibitory activity over a panel of 47 kinases, and its selectivity toward the FMS kinase was accidentally discovered. Compound 1 was tested over a panel of seven ovarian, two prostate, and six breast cancer cell lines at a single dose concentration of 10 mu M and showed high activity. It was further tested in a 5-dose mode to determine its IC50 and total growth inhibition (TGI) values over the 15 cell lines. Compound 1 showed high potency on the submicromolar scale and good efficacy. The cytotoxic effect of compound 1 over peritoneal macrophages was also investigated. Compound 1 demonstrated higher selectivity against different cancer cell lines compared with HS-27 fibroblasts. English WILEY-V C H VERLAG GMBH COLONY-STIMULATING FACTOR FACTOR-I CSF-1 RECEPTOR BREAST-CANCER EXPRESSION PROGRESSION TRANSCRIPTS MACROPHAGES CARCINOMA BEHAVIOR Cell-Based Biological Evaluation of a New Bisamide FMS Kinase Inhibitor Possessing Pyrrolo[3,2-c]pyridine Scaffold Article 10.1002/ardp.201400051 1 ARCHIV DER PHARMAZIE, v.347, no.9, pp.635 - 641 ARCHIV DER PHARMAZIE 347 9 635 641 scie scopus 000341776600004 2-s2.0-84925835528 Chemistry, Medicinal Chemistry, Multidisciplinary Pharmacology & Pharmacy Pharmacology & Pharmacy Chemistry Article COLONY-STIMULATING FACTOR FACTOR-I CSF-1 RECEPTOR BREAST-CANCER EXPRESSION PROGRESSION TRANSCRIPTS MACROPHAGES CARCINOMA BEHAVIOR Anticancer Bisamide Diarylamide FMS kinase Pyrrolo[3,2-c]pyridine