Seo, Youngmin Hwang, Jangsun Kim, Jieun Jeong, Yoon Hwang, Mintai P. Choi, Jonghoon 2024-01-20T09:02:02Z 2024-01-20T09:02:02Z 2021-09-04 2014-09 1176-9114 https://pubs.kist.re.kr/handle/201004/126390 Recently, various nanoscale materials, including silver (Ag) nanoparticles, have been actively studied for their capacity to effectively prevent bacterial growth. A critical challenge is to enhance the antibacterial properties of nanomaterials while maintaining their biocompatibility. The conjugation of multiple nanomaterials with different dimensions, such as spherical nanoparticles and high-aspect-ratio nanotubes, may increase the target-specific antibacterial capacity of the consequent nanostructure while retaining an optimal biocompatibility. In this study, multi-walled carbon nanotubes (MWCNTs) were treated with a mixture of acids and decorated with Ag nanoparticles via a chemical reduction of Ag cations by ethanol solution. The synthesized Ag-MWCNT complexes were characterized by transmission electron microscopy, X-ray diffractometry, and energy-dispersive X-ray spectroscopy. The antibacterial function of Ag-MWCNTs was evaluated against Methylobacterium spp. and Sphingomonas spp. In addition, the biocompatibility of Ag-MWCNTs was evaluated using both mouse liver hepatocytes (AML 12) and human peripheral blood mononuclear cells. Finally, we determined the minimum amount of Ag-MWCNTs required for a biocompatible yet effective antibacterial treatment modality. We report that 30 mu g/mL of Ag-MWCNTs confers antibacterial functionality while maintaining minimal cytotoxicity toward both human and animal cells. The results reported herein would be beneficial for researchers interested in the efficient preparation of hybrid nanostructures and in determining the minimum amount of Ag-MWCNTs necessary to effectively hinder the growth of bacteria. English DOVE MEDICAL PRESS LTD NANO-SILVER GENOTOXICITY DEPOSITION Antibacterial activity and cytotoxicity of multi-walled carbon nanotubes decorated with silver nanoparticles Article 10.2147/IJN.S69561 1 INTERNATIONAL JOURNAL OF NANOMEDICINE, v.9, pp.4621 - 4629 INTERNATIONAL JOURNAL OF NANOMEDICINE 9 4621 4629 scie scopus 000342441500001 2-s2.0-84907868430 Nanoscience & Nanotechnology Pharmacology & Pharmacy Science & Technology - Other Topics Pharmacology & Pharmacy Article NANO-SILVER GENOTOXICITY DEPOSITION antimicrobial nanoconstructs toxicity