Park, Joon Pyo Roh, Jong-Lyel Lee, Jeong Hyun Baek, Jung Hwan Gong, Gyungyub Cho, Kyung-Ja Choi, Seung-Ho Nam, Soon Yuhl Kim, Sang Yoon 2024-01-20T09:02:22Z 2024-01-20T09:02:22Z 2021-09-02 2014-09 0002-9610 https://pubs.kist.re.kr/handle/201004/126407 BACKGROUND: To examine predictive factors for subclinical central neck lymph node metastases (LNM) of papillary thyroid microcarcinoma (PTMC). METHODS: The clinical and pathological findings of 287 patients with clinically noninvasive, node-negative, solitary papillary thyroid carcinoma (PTC), who had undergone thyroidectomy plus central compartment neck dissection and showed pathologically confirmed nodal metastases, were analyzed. Predictive risk factors for central LNM were quantified. RESULTS: Pathologic LNM was identified in 63 (32.6%) PTMC patients and 48 (51.0%) PTC patients (tumor size >1 cm; P = .003). Tumor size (>.7 cm; P = .011), multifocality (P = .010), and microscopic extracapsular extension (P - .050) were significant variables predictive of central LNM from PTMC in univariate analysis. Tumor size (odds ratio 2.28, 95% confidence interval 1.19 to 4.38; P = .014) and multifocality (odds ratio 2.38, 95% confidence interval 1.14 to 4.93; P = .020) were independent variables predictive of central LNM in multivariate analysis. CONCLUSIONS: Cervical LNM is highly prevalent in clinically noninvasive, node-negative PTC. Central neck LNM is associated with larger tumor size and multifocality of PTMC. (C) 2014 Elsevier Inc. All rights reserved. English EXCERPTA MEDICA INC-ELSEVIER SCIENCE INC INCREASING INCIDENCE CENTRAL COMPARTMENT PROGNOSTIC-FACTORS UNITED-STATES MULTIFOCALITY DISSECTION CARCINOMA RECURRENCE PATTERN CANCER Risk factors for central neck lymph node metastasis of clinically noninvasive, node-negative papillary thyroid microcarcinoma Article 10.1016/j.amjsurg.2013.10.032 1 AMERICAN JOURNAL OF SURGERY, v.208, no.3, pp.412 - 418 AMERICAN JOURNAL OF SURGERY 208 3 412 418 scie scopus 000341149900012 2-s2.0-84906270312 Surgery Surgery Article INCREASING INCIDENCE CENTRAL COMPARTMENT PROGNOSTIC-FACTORS UNITED-STATES MULTIFOCALITY DISSECTION CARCINOMA RECURRENCE PATTERN CANCER Papillary thyroid carcinoma Subclinical lymph node metastasis Central neck Lymph node dissection Predictive factors