Cho, Youngjin Bach Quang Vu Bedair, Tarek M. Park, Bang Ju Joung, Yoon Ki Han, Dong Keun 2024-01-20T09:02:27Z 2024-01-20T09:02:27Z 2021-09-02 2014-09 0883-9115 https://pubs.kist.re.kr/handle/201004/126412 Crack prevention of biodegradable polymer coatings on drug-eluting stents was investigated by introducing a nano-coupled layer at the interface between the metal surface and the polymer coating layer using surface-initiated ring-opening polymerization of e-caprolactone. Poly(D,L-lactide-co-glycolide) coating on cobalt-chromium control and ricinoleic acid-poly(caprolactone)grafted cobalt-chromium was carried out using electrospraying. The cracking of the biodegradable polymer coating on drug-eluting stents during ballooning was addressed by introducing a nano-coupled interlayer on the cobalt-chromium surface. The ricinoleic acid-poly(caprolactone) nano-coupled interlayer and poly(D,L-lactide-co-glycolide)-coated top layer were characterized using attenuated total reflection Fourier transform infrared, contact angle, ellipsometry, X-ray photoelectron spectroscopy, and atomic force microscopy. Based on scratch tests, the nano-coupled samples had stronger interfacial adhesion compared to the control sample without the nano-coupled layer. Scanning electron microscope images indicated that the cracking on the poly(D,L-lactide-co-glycolide) coating was addressed. Introducing a nano-coupling interlayer may be an important strategy to preventing polymer coating cracking on drug-eluting stents. English SAGE PUBLICATIONS LTD DRUG-ELUTING STENTS CORONARY STENTS VASCULAR STENTS L-LACTIDE SURFACE DURABILITY ADHESION RELEASE PLASMA ARTERY Crack prevention of biodegradable polymer coating on metal facilitated by a nano-coupled interlayer Article 10.1177/0883911514547094 1 JOURNAL OF BIOACTIVE AND COMPATIBLE POLYMERS, v.29, no.5, pp.515 - 526 JOURNAL OF BIOACTIVE AND COMPATIBLE POLYMERS 29 5 515 526 scie scopus 000342896900008 2-s2.0-84907549014 Biotechnology & Applied Microbiology Materials Science, Biomaterials Polymer Science Biotechnology & Applied Microbiology Materials Science Polymer Science Article DRUG-ELUTING STENTS CORONARY STENTS VASCULAR STENTS L-LACTIDE SURFACE DURABILITY ADHESION RELEASE PLASMA ARTERY Drug-eluting stent cobalt-chromium surface modification polymer brush nano-coupling poly(D,L-lactide-co-glycolide)