Kang, Heesung Son, Taeyoon Lee, Aeju Youn, Inchan Seo, Dong Hyun Kim, Han Sung Jung, Byungjo 2024-01-20T09:02:37Z 2024-01-20T09:02:37Z 2021-09-02 2014-09 0268-8921 https://pubs.kist.re.kr/handle/201004/126421 The present study aimed to investigate the effects of a minimally invasive laser needle system (MILNS) on the acute progression of arthritis. Previous studies showed controversial clinical results regarding the effects of low-level laser therapy on arthritis, with the outcomes depending upon stimulation parameters such as laser wavelength and dosage. Based on the positive effects of MILNS on osteoporotic mice, we hypothesized that MILNS could potentially suppress the progression of arthritis owing to its biostimulation effects. Eight C57BL/6 mice with complete Freund's adjuvant (CFA)-induced arthritis were used as acute progression arthritis models and divided into the laser and control groups (n = 4 each). In the laser group, after minimally invasive laser stimulation, laser speckle contrast images (LSCIs) were obtained every 6 h for a total of 108 h. The LSCIs in the control group were obtained without laser stimulation. The effects of MILNS on the acute progression of arthritis were indirectly evaluated by calculating the paw area and the average laser speckle index (LSI) at the arthritis-induced area. Moreover, the macrophage population was estimated in the arthritis-induced area. Compared to the control group, the laser group showed (1) lower relative variations of the paw area, (2) lower average LSI in the arthritis-induced area, and (3) lower macrophage population in the arthritis-induced area. These results indicate that MILNS may suppress the acute progression of CFA-induced arthritis in mice and may thus be used as a potential treatment modality of arthritis in clinics. English SPRINGER LONDON LTD RHEUMATOID-ARTHRITIS THERAPY BONE IRRADIATION RATS MICE The effects of a minimally invasive laser needle system on complete Freund's adjuvant-induced arthritis Article 10.1007/s10103-014-1555-y 1 LASERS IN MEDICAL SCIENCE, v.29, no.5, pp.1599 - 1606 LASERS IN MEDICAL SCIENCE 29 5 1599 1606 scie scopus 000341503500010 Engineering, Biomedical Surgery Engineering Surgery Article RHEUMATOID-ARTHRITIS THERAPY BONE IRRADIATION RATS MICE Arthritis Low-level laser therapy Laser speckle contrast image Minimally invasive