Kim, Ji Young Son, Myung-Hee Choi, Kihang Baek, Du-Jong Ko, Min Kyung Lim, Eun Jeong Pae, Ae Nim Keum, Gyochang Lee, Jae Kyun Cho, Yong Seo Choo, Hyunah Lee, Youn Woo Moon, Byung Seok Lee, Byung Cheol Lee, Ho-Young Min, Sun-Joon 2024-01-20T09:03:19Z 2024-01-20T09:03:19Z 2021-09-02 2014-08-20 0253-2964 https://pubs.kist.re.kr/handle/201004/126457 The synthesis and in vivo evaluation of 5-methoxy-2-(phenylethynyl)quinoline (MPEQ) 3 as a potential mGluR5 selective radioligand is described. We have identified MPEQ 3 exhibiting the analgesic effect in the neuropathic pain animal model. The effect of mGluR5 on neuronal activity in rat brain was evaluated through FDG/PET imaging in the presence of MPEQ 3. In addition, the PET study of [C-11]MPEQ 3 proved that accumulation of [C-11]MPEQ 3 in rat brain was correlated to the localization of the mGluR5. English WILEY-V C H VERLAG GMBH RAT MODEL PAIN LOCALIZATION ANTAGONIST ALLODYNIA PET Synthesis and In vivo Evaluation of 5-Methoxy-2-(phenylethynyl)quinoline (MPEQ) and [C-11]MPEQ Targeting Metabotropic Glutamate Receptor 5 (mGluR5) Article 10.5012/bkcs.2014.35.8.2304 1 BULLETIN OF THE KOREAN CHEMICAL SOCIETY, v.35, no.8, pp.2304 - 2310 BULLETIN OF THE KOREAN CHEMICAL SOCIETY 35 8 2304 2310 scie scopus kci ART001897371 000340690600014 2-s2.0-84906351387 Chemistry, Multidisciplinary Chemistry Article RAT MODEL PAIN LOCALIZATION ANTAGONIST ALLODYNIA PET MPEQ Metabotropic glutamate receptor 5 (mGluR5) in vivo PET imaging Neuropathic pain