Park, Kyungjoon Song, Sukwoon Hong, Ingie Song, Beomjong Kim, Jeongyeon Park, Sungmo Lee, Junuk Song, Sangho An, Bobae Kim, Jihye Lee, C. Justin Shin, Ki Soon Choi, Sukwoo Lee, Sukwon 2024-01-20T09:03:46Z 2024-01-20T09:03:46Z 2021-09-04 2014-08-08 1662-5153 https://pubs.kist.re.kr/handle/201004/126481 There is conflicting evidence regarding whether calcium-permeable receptors are removed during group I mGluR-mediated synaptic depression. In support of this hypothesis, AMPAR rectification, a correlative index of the synaptic expression of GluA2-lacking calcium permeable AMPARs (CP-AMPARs), is known to decrease after the induction of several types of group I mGluR-mediated long-term depression (LTD), suggesting that a significant proportion of synaptic CP-AMPARs is removed during synaptic depression. We have previously demonstrated that fear conditioning induced synaptic potentiation in the lateral amygdala is reversed by group 1 mGluR-mediated depotentiation. Here, we examined whether CP-AMPARs are removed by mGluR1-mediated depotentiation of fear conditioning-induced synaptic potentiation. The synaptic expression of CP-AMPARs was negligible before, increased significantly 12 h after, and returned to baseline 48 h after fear conditioning, as evidenced by the changes in the sensitivity of lateral amygdala synaptic responses to NASPM. Importantly, the sensitivity to NASPM was not altered after induction of depotentiation. Our findings, together with previous results, suggest that the removal of CP-AM PARs is not required for the depotentiation of fear conditioning-induced synaptic potentiation at lateral amygdala synapses. English FRONTIERS MEDIA SA LONG-TERM DEPRESSION METABOTROPIC GLUTAMATE-RECEPTOR FEAR MEMORY DENTATE GYRUS POTENTIATION PHOSPHORYLATION EXTINCTION ACTIVATION LTD INVOLVEMENT Group I mGluR-dependent depotentiation in the lateral amygdala does not require the removal of calcium-permeable AMPA receptors Article 10.3389/fnbeh.2014.00269 1 FRONTIERS IN BEHAVIORAL NEUROSCIENCE, v.8 FRONTIERS IN BEHAVIORAL NEUROSCIENCE 8 scie scopus 000340902900001 2-s2.0-84905703342 Behavioral Sciences Neurosciences Behavioral Sciences Neurosciences & Neurology Article LONG-TERM DEPRESSION METABOTROPIC GLUTAMATE-RECEPTOR FEAR MEMORY DENTATE GYRUS POTENTIATION PHOSPHORYLATION EXTINCTION ACTIVATION LTD INVOLVEMENT calcium-permeable AMPA receptors synaptic depotentiation fear conditioning lateral a mygdala long-term depression