Yun, Jun Han, Minsoo Song, Chiman Cheon, Seung Hoon Choi, Kihang Hahn, Hoh-Gyu 2024-01-20T09:03:59Z 2024-01-20T09:03:59Z 2021-09-05 2014-08-01 0960-894X https://pubs.kist.re.kr/handle/201004/126492 We report the synthesis of 3-phenethylazetidine derivatives 2 and their biological activities against 5-HT, NE and DA transporters as well as microsomal stability, CYP inhibition, and hERG inhibition profiles. Compound 2at showed most potent triple reuptake inhibitor with good selectivity as a candidate for depression. (C) 2014 Elsevier Ltd. All rights reserved. English Pergamon Press Ltd. BUPROPION COMBINATION Synthesis and biological evaluation of 3-phenethylazetidine derivatives as triple reuptake inhibitors Article 10.1016/j.bmcl.2014.06.026 1 Bioorganic & Medicinal Chemistry Letters, v.24, no.15, pp.3234 - 3237 Bioorganic & Medicinal Chemistry Letters 24 15 3234 3237 scie scopus 000339228700002 2-s2.0-84904065583 Chemistry, Medicinal Chemistry, Organic Pharmacology & Pharmacy Chemistry Article BUPROPION COMBINATION Depression Antidepressant Triple reuptake inhibitor 3-Phenethylazetidines