Sengupta, Sandip Sim, Taebo 2024-01-20T09:04:15Z 2024-01-20T09:04:15Z 2022-01-10 2014-08 1434-193X https://pubs.kist.re.kr/handle/201004/126506 A highly efficient (10.1% overall yield) and convergent (longest linear sequence of 16 steps) synthesis of mupirocin H has been achieved, starting from commercially available (+)-(R)-Roche ester. The route relies on an efficient Grubbs cross-metathesis reaction to generate a key, late-stage E-olefin intermediate, and a cobalt-catalysed diastereoselective Reformatsky reaction to produce a beta-hydroxy ester that serves as a late-stage intermediate. English WILEY-V C H VERLAG GMBH ENANTIOSELECTIVE SYNTHESIS REFORMATSKY REACTIONS DIMETHYL-SULFOXIDE CHIRAL SYNTHESIS GENE-CLUSTER OXIDATION ALCOHOLS COBALT ORGANOBORANES SELECTIVITY A Concise Synthesis of Mupirocin H Using a Cross-Metathesis-Based Strategy Article 10.1002/ejoc.201402442 1 EUROPEAN JOURNAL OF ORGANIC CHEMISTRY, v.2014, no.23, pp.5063 - 5070 EUROPEAN JOURNAL OF ORGANIC CHEMISTRY 2014 23 5063 5070 scie scopus 000340460700016 2-s2.0-84905565905 Chemistry, Organic Chemistry Article ENANTIOSELECTIVE SYNTHESIS REFORMATSKY REACTIONS DIMETHYL-SULFOXIDE CHIRAL SYNTHESIS GENE-CLUSTER OXIDATION ALCOHOLS COBALT ORGANOBORANES SELECTIVITY Total synthesis Natural products Polyketides Metathesis Reformatsky reaction