Hwang, Jin-Hee Lee, Kyu-Sup Joo, Jong-Kil Wang, Tao Son, Jung-Bin Park, Jung-Ha Hwang, Dae-Youn Choi, Man-Ho Lee, Hong-Gu 2024-01-20T09:04:19Z 2024-01-20T09:04:19Z 2021-09-05 2014-08 1791-2997 https://pubs.kist.re.kr/handle/201004/126509 The present study aimed to examine potential biomarkers for the diagnosis of endometriosis. A plasma-based proteomic approach, including 2-dimentional electrophoresis and mass spectrometry, was used. Samples were obtained from patients with (n=15) and without (n=15) endometriosis, or from mice with surgically induced endometriosis. Seven spots corresponding to six differentially expressed proteins were identified in the human plasma samples. However, only haptoglobin (Hp) was identified to be significantly decreased in the plasma levels of patients with endometriosis (P<0.05) and in mice with surgically induced endometriosis (P<0.05). The results demonstrated that Hp was downregulated in females with endometriosis, and it therefore, may be a useful diagnostic tool as a biomarker of endometriosis. English SPANDIDOS PUBL LTD OXIDATIVE STRESS MICROARRAY ANALYSIS SERUM MARKER EXPRESSION DIAGNOSIS AUTOANTIBODY CA-125 FLUID CELLS WOMEN Identification of biomarkers for endometriosis in plasma from patients with endometriosis using a proteomics approach Article 10.3892/mmr.2014.2291 1 MOLECULAR MEDICINE REPORTS, v.10, no.2, pp.725 - 730 MOLECULAR MEDICINE REPORTS 10 2 725 730 scie scopus 000339127600022 2-s2.0-84903317841 Oncology Medicine, Research & Experimental Oncology Research & Experimental Medicine Article OXIDATIVE STRESS MICROARRAY ANALYSIS SERUM MARKER EXPRESSION DIAGNOSIS AUTOANTIBODY CA-125 FLUID CELLS WOMEN endometriosis haptoglobin plasma proteomics