Kang, Mijeong Jung, Seungmoon Zhang, Huanan Kang, Taejoon Kang, Hosuk Yoo, Youngdong Hong, Jin-Pyo Ahn, Jae-Pyoung Kwak, Juhyoun Jeon, Daejong Kotov, Nicholas A. Kim, Bongsoo 2024-01-20T09:04:33Z 2024-01-20T09:04:33Z 2021-09-05 2014-08 1936-0851 https://pubs.kist.re.kr/handle/201004/126521 Size reduction of neural electrodes is essential for improving the functionality of neuroprosthetic devices, developing potent therapies for neurological and neurodegenerative diseases, and long-term brain computer interfaces. Typical neural electrodes are micromanufactured devices with dimensions ranging from tens to hundreds of micrometers. Their further miniaturization is necessary to reduce local tissue damage and chronic immunological reactions of the brain. Here we report the neural electrode with subcellular dimensions based on single-crystalline gold nanowires (NWs) with a diameter of similar to 100 nm. Unique mechanical and electrical properties of defect-free gold NWs enabled their implantation and recording of single neuron-activities in a live mouse brain despite a similar to 50 x reduction of the size compared to the closest analogues. Reduction of electrode dimensions enabled recording of neural activity with improved spatial resolution and differentiation of brain activity in response to different social situations for mice. The successful localization of the epileptic seizure center was also achieved using a multielectrode probe as a demonstration of the diagnostics potential of NW electrodes. This study demonstrated the realism of single-neuron recording using subellular-sized electrodes that may be considered a pivotal point for use in diverse studies of chronic brain diseases. English AMER CHEMICAL SOC SURFACES AU MICROELECTRODES DEPOSITION Subcellular Neural Probes from Single-Crystal Gold Nanowires Article 10.1021/nn5024522 1 ACS NANO, v.8, no.8, pp.8182 - 8189 ACS NANO 8 8 8182 8189 scie scopus 000340992300063 2-s2.0-84906706586 Chemistry, Multidisciplinary Chemistry, Physical Nanoscience & Nanotechnology Materials Science, Multidisciplinary Chemistry Science & Technology - Other Topics Materials Science Article SURFACES AU MICROELECTRODES DEPOSITION gold nanowire nanoelectrode neural implants neuroprosthetics brain-machine interface neurodegenerative disease epilepsy subcellular-sized implants BRAIN initiative single-neuron detection electrode miniaturization long-term neural recordings paralysis