Ku, Sook Hee Kim, Kwangmeyung Choi, Kuiwon Kim, Sun Hwa Kwon, Ick Chan 2024-01-20T09:04:42Z 2024-01-20T09:04:42Z 2021-09-05 2014-08 2192-2640 https://pubs.kist.re.kr/handle/201004/126529 RNA interference (RNAi) is a naturally occurring regulatory process that controls posttranscriptional gene expression. Small interfering RNA (siRNA), a common form of RNAi-based therapeutics, offers new opportunities for cancer therapy via silencing specific genes, which are associated to cancer progress. However, clinical applications of RNAi-based therapy are still limited due to the easy degradation of siRNA during body circulation and the difficulty in the delivery of siRNA to desired tissues and cells. Thus, there have been many efforts to develop efficient siRNA delivery systems, which protect siRNA from serum nucleases and deliver siRNA to the intracellular region of target cells. Here, the recent advances in siRNA nanocarriers, which possess tumor-targeting ability are reviewed; various nanoparticle systems and their antitumor effects are summarized. The development of multifunctional nanocarriers for theranostics or combinatorial therapy is also discussed. English WILEY MESOPOROUS SILICA NANOPARTICLES SMALL INTERFERING RNA OVERCOME DRUG-RESISTANCE IN-VIVO BIODISTRIBUTION MEDIATED CO-DELIVERY LOW-MOLECULAR-WEIGHT GOLD NANOPARTICLES SYSTEMIC DELIVERY TRANSFECTION EFFICIENCY OXIDE NANOPARTICLES Tumor-Targeting Multifunctional Nanoparticles for siRNA Delivery: Recent Advances in Cancer Therapy Article 10.1002/adhm.201300607 1 ADVANCED HEALTHCARE MATERIALS, v.3, no.8, pp.1182 - 1193 ADVANCED HEALTHCARE MATERIALS 3 8 1182 1193 scie scopus 000340550500005 2-s2.0-84906077659 Engineering, Biomedical Nanoscience & Nanotechnology Materials Science, Biomaterials Engineering Science & Technology - Other Topics Materials Science Review MESOPOROUS SILICA NANOPARTICLES SMALL INTERFERING RNA OVERCOME DRUG-RESISTANCE IN-VIVO BIODISTRIBUTION MEDIATED CO-DELIVERY LOW-MOLECULAR-WEIGHT GOLD NANOPARTICLES SYSTEMIC DELIVERY TRANSFECTION EFFICIENCY OXIDE NANOPARTICLES Cancer therapy Multifunctional nanoparticles SiRNA delivery Tumor targeting