Lee, So Jin Min, Hyun Su Ku, Sook Hee Son, Sohee Kwon, Ick Chan Kim, Sun Hwa Kim, Kwangmeyung 2024-01-20T09:04:43Z 2024-01-20T09:04:43Z 2021-09-05 2014-08 1743-5889 https://pubs.kist.re.kr/handle/201004/126530 A natural based polymer, chitosan has received widespread attention in drug delivery systems due to its valuable physicochemical and biological characteristics. In particular, hydrophobic moiety-conjugated glycol chitosan can form amphiphilic self-assembled glycol chitosan nanoparticles (GCNPs) and simultaneously encapsulate hydrophobic drug molecules inside their hydrophobic core. This GCNP-based drug delivery systems exhibit excellent tumor-homing efficacy, attributed to the long blood circulation and the enhanced permeability and retention effect; this tumor-targeting drug delivery results in improved therapeutic efficiency. In this review, we describe the requisite properties of GCNPs for cancer therapy as well as imaging for diagnosis, such as their basic characteristics, in vitro delivery efficiency and in vivo tumor-targeting ability. English FUTURE MEDICINE LTD SELF-ASSEMBLED NANOPARTICLES DRUG-DELIVERY POLYMERIC NANOPARTICLES PHOTODYNAMIC THERAPY ANTITUMOR EFFICACY CELLULAR UPTAKE IRON-OXIDE SIRNA NANOCARRIERS DERIVATIVES Tumor-targeting glycol chitosan nanoparticles as a platform delivery carrier in cancer diagnosis and therapy Article 10.2217/NNM.14.99 1 NANOMEDICINE, v.9, no.11, pp.1697 - 1713 NANOMEDICINE 9 11 1697 1713 scie scopus 000343903400009 2-s2.0-84908866688 Biotechnology & Applied Microbiology Nanoscience & Nanotechnology Biotechnology & Applied Microbiology Science & Technology - Other Topics Review SELF-ASSEMBLED NANOPARTICLES DRUG-DELIVERY POLYMERIC NANOPARTICLES PHOTODYNAMIC THERAPY ANTITUMOR EFFICACY CELLULAR UPTAKE IRON-OXIDE SIRNA NANOCARRIERS DERIVATIVES amphiphilic nanoparticles cancer therapy diagnosis EPR glycol chitosan