Stark, Eran Roux, Lisa Eichler, Ronny Senzai, Yuta Royer, Sebastien Buzsaki, Gyoergy 2024-01-20T09:30:59Z 2024-01-20T09:30:59Z 2021-09-05 2014-07-16 0896-6273 https://pubs.kist.re.kr/handle/201004/126587 High-frequency ripple oscillations, observed most prominently in the hippocampal CA1 pyramidal layer, are associated with memory consolidation. The cellular and network mechanisms underlying the generation, frequency control, and spatial coherence of the rhythm are poorly understood. Using multisite optogenetic manipulations in freely behaving rodents, we found that depolarization of a small group of nearby pyramidal cells was sufficient to induce high-frequency oscillations, whereas closed-loop silencing of pyramidal cells or activation of parvalbumin-(PV) or somatostatin-immunoreactive interneurons aborted spontaneously occurring ripples. Focal pharmacological blockade of GABA(A) receptors abolished ripples. Localized PV interneuron activation paced ensemble spiking, and simultaneous induction of high-frequency oscillations at multiple locations resulted in a temporally coherent pattern mediated by phase-locked interneuron spiking. These results constrain competing models of ripple generation and indicate that temporally precise local interactions between excitatory and inhibitory neurons support ripple generation in the intact hippocampus. English CELL PRESS HIGH-FREQUENCY OSCILLATIONS SHARP-WAVE-RIPPLES IN-VITRO GAMMA OSCILLATIONS RAT HIPPOCAMPUS SPATIAL MEMORY BEHAVING RAT NEURONS NETWORKS COMPLEXES Pyramidal Cell-Interneuron Interactions Underlie Hippocampal Ripple Oscillations Article 10.1016/j.neuron.2014.06.023 1 NEURON, v.83, no.2, pp.467 - 480 NEURON 83 2 467 480 scie scopus 000340478700020 2-s2.0-84904336339 Neurosciences Neurosciences & Neurology Article HIGH-FREQUENCY OSCILLATIONS SHARP-WAVE-RIPPLES IN-VITRO GAMMA OSCILLATIONS RAT HIPPOCAMPUS SPATIAL MEMORY BEHAVING RAT NEURONS NETWORKS COMPLEXES