우준성 이창준 조승목 2024-01-20T09:33:26Z 2024-01-20T09:33:26Z 2021-09-06 2014-06 1226-2560 https://pubs.kist.re.kr/handle/201004/126711 Isoliquiritigenin (ILTG) is a chalcone compound and shows various pharmacological properties, including antioxidant and anti-inflammatory activities. In recent study, we have reported a novel role of ILTG in sleep through a positive allosteric modulation ofgamma-aminobutyric acid type A (GABAA)-benzodiazepine (BZD) receptors. However, the effect of ILTG in GABAAR-mediatedsynaptic response in brain has not been tested yet. Here we report that ILTG significantly prolonged the decay of spontaneousinhibitory postsynaptic currents (sIPSCs) mediated by GABAAR in mouse hippocampal CA1 pyramidal neurons without affectingamplitude and frequency of sIPSCs. This enhancement was fully inhibited by flumazenil (FLU), a specific GABAA-BZD receptorantagonist. These results suggest a potential role of ILTG as a modulator of GABAergic synaptic transmission. English 한국뇌신경과학회 Isoliquiritigenin, a Chalcone Compound, Enhances Spontaneous Inhibitory Postsynaptic Response Article 2 Experimental Neurobiology, v.23, no.2, pp.163 - 168 Experimental Neurobiology 23 2 163 168 kci other ART001887224 Isoliquiritigenin GABAA-BZD receptor sIPSC