Li, Hailan Kim, Jandi Hahn, Hoh-Gyu Yun, Jun Jeong, Hyo-Soon Yun, Hye-Young Baek, Kwang Jin Kwon, Nyoun Soo Min, Young Sil Park, Kyoung-Chan Kim, Dong-Seok 2024-01-20T09:34:17Z 2024-01-20T09:34:17Z 2021-09-04 2014-06 1226-4512 https://pubs.kist.re.kr/handle/201004/126756 The purpose of this study is to characterize the effects of KHG26792 (3-(naphthalen-2-yl(propoxy) methyl)azetidine hydrochloride), a potential skin whitening agent, on melanin synthesis and identify the underlying mechanism of action. Our data showed that KHG26792 significantly reduced melanin synthesis in a dose-dependent manner. Additionally, KHG26792 downregulated microphthalmia-associated transcription factor (MITF) and tyrosinase, the rate-limiting enzyme in melanogenesis, although tyrosinase was not inhibited directly. KHG26792 activated extracellular signal-regulated kinase (ERK), whereas an ERK pathway inhibitor, PD98059, rescued KHG26792-induced hypopigmentation. These results suggest that KHG26792 decreases melanin production via ERK activation. Moreover, the hypopiginentary effects of KHG26792 were confirmed in a pigmented skin equivalent model using Cervi comas Colla (deer antler glue), in which the color of the pigmented artificial skin became lighter after treatment with KHG26792. In summary, our findings suggest that KHG26792 is a novel skin whitening agent. English KOREAN JOURNAL OF PHYSIOLOGY & PHARMACOLOGY HUMAN MELANOCYTES ERK ACTIVATION IN-VITRO PIGMENTATION MELANOGENESIS TYROSINASE KHG26792 Inhibits Melanin Synthesis in Mel-Ab Cells and a Skin Equivalent Model Article 10.4196/kjpp.2014.18.3.249 1 KOREAN JOURNAL OF PHYSIOLOGY & PHARMACOLOGY, v.18, no.3, pp.249 - 254 KOREAN JOURNAL OF PHYSIOLOGY & PHARMACOLOGY 18 3 249 254 scie scopus kci ART001888595 000337556200008 2-s2.0-84904362337 Pharmacology & Pharmacy Physiology Pharmacology & Pharmacy Physiology Article HUMAN MELANOCYTES ERK ACTIVATION IN-VITRO PIGMENTATION MELANOGENESIS TYROSINASE ERK KHG26792 Melanogenesis Skin equivalent Tyrosinase