Stewart, Adam Michael Braubach, Oliver Spitsbergen, Jan Gerlai, Robert Kalueffl, Allan V. 2024-01-20T10:00:24Z 2024-01-20T10:00:24Z 2022-01-10 2014-05 0166-2236 https://pubs.kist.re.kr/handle/201004/126809 The zebrafish (Danio rerio) is emerging as a new important species for studying mechanisms of brain function and dysfunction. Focusing on selected central nervous system (CNS) disorders (brain cancer, epilepsy, and anxiety) and using them as examples, we discuss the value of zebrafish models in translational neuroscience. We further evaluate the contribution of zebrafish to neuro-imaging, circuit level, and drug discovery research. Outlining the role of zebrafish in modeling a wide range of human brain disorders, we also summarize recent applications and existing challenges in this field. Finally, we emphasize the potential of zebrafish models in behavioral phenomics and high-throughput genetic/small molecule screening, which is critical for CNS drug discovery and identifying novel candidate genes. English ELSEVIER SCIENCE LONDON DANIO-RERIO ADULT ZEBRAFISH LARVAL ZEBRAFISH KNOCKOUT MICE BEHAVIORAL-RESPONSES IN-VIVO BIPOLAR DISORDER SOCIAL-BEHAVIOR FEAR RESPONSES ANXIETY Zebrafish models for translational neuroscience research: from tank to bedside Article 10.1016/j.tins.2014.02.011 1 TRENDS IN NEUROSCIENCES, v.37, no.5, pp.264 - 278 TRENDS IN NEUROSCIENCES 37 5 264 278 scie scopus 000336113700004 2-s2.0-84899909435 Neurosciences Neurosciences & Neurology Review DANIO-RERIO ADULT ZEBRAFISH LARVAL ZEBRAFISH KNOCKOUT MICE BEHAVIORAL-RESPONSES IN-VIVO BIPOLAR DISORDER SOCIAL-BEHAVIOR FEAR RESPONSES ANXIETY brain disorders anxiety epilepsy cancer zebrafish biomarkers