Choi, Jonghoon Hwang, Mintai P. Lee, Jong-Wook Lee, Kwan Hyi 2024-01-20T10:01:03Z 2024-01-20T10:01:03Z 2021-09-05 2014-05 1176-9114 https://pubs.kist.re.kr/handle/201004/126842 Mesenchymal stem cells (MSCs) have been thought to hold potential as a mode of therapy for immuno-related pathologies, particularly for autoimmune diseases. Despite their potential, the interaction between MSCs and T cells, key players in the pathophysiology of autoimmune diseases, is not yet well understood, thereby preventing further clinical progress. A major obstacle is the highly heterogeneous nature of MSCs in vitro. Unfortunately, bulk assays do not provide information with regard to cell-cell contributions that may play a critical role in the overall cellular response. To address these issues, we investigated the interaction between smaller subsets of MSCs and CD4 T cells in a microwell array. We demonstrate that MSCs appear capable of modulating the T cell proliferation rate in response to persistent cell-cell interactions, and we anticipate the use of our microwell array in the classification of subpopulations within MSCs, ultimately leading to specific therapeutic interventions. English DOVE MEDICAL PRESS LTD IMMUNOMODULATORY PROPERTIES A glimpse into the interactions of cells in a microenvironment: the modulation of T cells by mesenchymal stem cells Article 10.2147/IJN.S50767 1 INTERNATIONAL JOURNAL OF NANOMEDICINE, v.9, pp.127 - 139 INTERNATIONAL JOURNAL OF NANOMEDICINE 9 127 139 scie scopus 000349961100011 2-s2.0-84900441031 Nanoscience & Nanotechnology Pharmacology & Pharmacy Science & Technology - Other Topics Pharmacology & Pharmacy Article IMMUNOMODULATORY PROPERTIES mesenchymal stem cell T cell microwell array