Jung, Sang Hoon Kim, Kyung-A Sohn, Sea Woon Yang, Sung Jae 2024-01-20T10:01:10Z 2024-01-20T10:01:10Z 2021-09-04 2014-05 0816-4622 https://pubs.kist.re.kr/handle/201004/126849 BackgroundThis study aimed to investigate the levels of aqueous humour cytokines in the eyes of patients with central serous chorioretinopathy (CSC), who received an intravitreal injection of bevacizumab, and to evaluate the differences in cytokine levels between bevacizumab responders and non-responders. MethodsAqueous humour samples were collected from 39 eyes of 39 patients with CSC and 25 eyes of 25 control patients undergoing cataract surgery and were analysed using Multiplex bead assays. We compared the cytokine levels in patients with CSC (responders and non-responders) and control subjects. After intravitreal injections of bevacizumab in patients with CSC, we evaluated the changes in visual acuity and optical coherence tomographic parameters. ResultsSignificantly increased levels of interferon gamma-induced protein (IP-10) were detected in the aqueous humour of eyes from patients with CSC compared to controls (p = 0.036). Vascular endothelial growth factor (VEGF) levels were significantly higher in bevacizumab responders than in non-responders (p = 0.021). The concentrations of the other cytokines investigated did not differ significantly between patients with CSC and control subjects or between responders and non-responders. ConclusionThe results of the present study suggest that IP-10 and VEGF may contribute to the pathogenesis of CSC. It is clear that intravitreal bevacizumab was helpful in some of the patients with CSC, who showed higher levels of VEGF in the aqueous humour. However, the true effect and the rationale of anti-VEGF injection treatment in patients with CSC remain to be elucidated. Our results suggest that patients with CSC may be more susceptible to VEGF and/or other cytokines than the normal population. English WILEY-BLACKWELL ENDOTHELIAL GROWTH-FACTOR DIABETIC MACULAR EDEMA RETINAL VEIN OCCLUSION GUIDED PHOTODYNAMIC THERAPY X-C CHEMOKINES TERM FOLLOW-UP IN-VIVO CHOROIDAL NEOVASCULARIZATION INTRAVITREAL TRIAMCINOLONE INFLAMMATORY MARKERS Cytokine levels of the aqueous humour in central serous chorioretinopathy Article 10.1111/cxo.12125 1 CLINICAL AND EXPERIMENTAL OPTOMETRY, v.97, no.3, pp.264 - 269 CLINICAL AND EXPERIMENTAL OPTOMETRY 97 3 264 269 scie scopus 000335001900012 2-s2.0-84899618193 Ophthalmology Ophthalmology Article ENDOTHELIAL GROWTH-FACTOR DIABETIC MACULAR EDEMA RETINAL VEIN OCCLUSION GUIDED PHOTODYNAMIC THERAPY X-C CHEMOKINES TERM FOLLOW-UP IN-VIVO CHOROIDAL NEOVASCULARIZATION INTRAVITREAL TRIAMCINOLONE INFLAMMATORY MARKERS aqueous humour bevacizumab central serous chorioretinopathy cytokines