Cha, Kook Jin Lih, Eugene Choi, Jiyeon Joung, Yoon Ki Ahn, Dong Jun Han, Dong Keun 2024-01-20T10:01:11Z 2024-01-20T10:01:11Z 2021-09-04 2014-05 1616-5187 https://pubs.kist.re.kr/handle/201004/126850 Specific biodegradable polymers having shape-memory properties through "polymer-blend'' method are investigated and their shape-switching in body temperature (37 degrees C) is characterized. Poly(L-lactide-co-caprolactone) (PLCL) and poly(L-lactide-co-glycolide) (PLGA) are dissolved in chloroform and the films of several blending ratios of PLCL/PLGA are prepared by solvent casting. The shape-memory properties of films are also examined using dynamic mechanical analysis (DMA). Among the blending ratios, the PLCL50/PLGA50 film shows good performance of shape-fixity and shape-recovery based on glass transition temperature. It displays that the degree of shape recovery is 100% at 37 degrees C and the shape recovery proceeds within only 15 s. In vitro biocompatibility studies are shown to have good blood compatibility and cytocompatibility for the PLCL50/PLGA50 films. It is expected that this blended biodegradable polymer can be potentially used as a material for blood-contacting medical devices such as a self-expended vascular polymer stents and vascular closure devices in biomedical applications. English WILEY-V C H VERLAG GMBH BLOCK-COPOLYMERS COMPOSITES STENTS DEGRADATION STRESS Shape-Memory Effect by Specific Biodegradable Polymer Blending for Biomedical Applications Article 10.1002/mabi.201300481 1 MACROMOLECULAR BIOSCIENCE, v.14, no.5, pp.667 - 678 MACROMOLECULAR BIOSCIENCE 14 5 667 678 scie scopus 000336244100007 Biochemistry & Molecular Biology Materials Science, Biomaterials Polymer Science Biochemistry & Molecular Biology Materials Science Polymer Science Article BLOCK-COPOLYMERS COMPOSITES STENTS DEGRADATION STRESS biodegradable polymers biomedical applications glass transition temperature polymer blends shape memory polymers