Yoo, Ji-Hye Kang, Kyungsu Yun, Ji Ho Kim, Mi Ae Nho, Chu Won 2024-01-20T10:03:19Z 2024-01-20T10:03:19Z 2021-09-04 2014-04 1096-620X https://pubs.kist.re.kr/handle/201004/126959 Alcohol is a severe hepatotoxicant that causes liver abnormalities such as steatosis, cirrhosis, and hepatocarcinoma. Crepidiastrum denticulatum (CD) is a well-known, traditionally consumed vegetable in Korea, which was recently reported to have bioactive compounds with detoxification and antioxidant properties. In this study, we report the hepatoprotective effect of CD extract against chronic alcohol-induced liver damage in vivo. The rats that were given CD extract exhibited decreased alanine aminotransferase, aspartate aminotransferase, and c-glutamyl transpeptidase activities, which are liver damage markers that are typically elevated by alcohol consumption. The results were confirmed by histopathology with hematoxylin and eosin staining. Chronic alcohol consumption induced the formation of alcoholic fatty liver. However, treatment with CD extract dramatically decreased the hepatic lipid droplets. Treatment with CD extract also restored the antioxidative capacity and lipid peroxidation of the liver that had been changed by alcohol consumption. Furthermore, treatment with CD extract normalized the activities of the antioxidative enzymes superoxide dismutase, catalase, glutathione reductase, and glutathione peroxidase, which had been decreased by alcohol consumption. The results indicate that CD extract has protective effects against chronic alcohol hepatotoxicity in rats by increasing the liver's antioxidant capacity, and has potential as a dietary supplement intervention for patients with alcohol-induced liver damage. English MARY ANN LIEBERT, INC CHRONIC ETHANOL-CONSUMPTION OXIDATIVE STRESS SUPEROXIDE-DISMUTASE HOVENIA-DULCIS CELLS CYCLODEXTRINS REDUCTASE CATALASE ASSAYS ACID Crepidiastrum denticulatum Extract Protects the Liver Against Chronic Alcohol-Induced Damage and Fat Accumulation in Rats Article 10.1089/jmf.2013.2799 1 JOURNAL OF MEDICINAL FOOD, v.17, no.4, pp.432 - 438 JOURNAL OF MEDICINAL FOOD 17 4 432 438 scie scopus kci ART001868668 000336217200004 2-s2.0-84922538425 Chemistry, Medicinal Food Science & Technology Nutrition & Dietetics Pharmacology & Pharmacy Food Science & Technology Nutrition & Dietetics Article CHRONIC ETHANOL-CONSUMPTION OXIDATIVE STRESS SUPEROXIDE-DISMUTASE HOVENIA-DULCIS CELLS CYCLODEXTRINS REDUCTASE CATALASE ASSAYS ACID antioxidative capacity chronic alcohol consumption Crepidiastrum denticulatum hepatoprotection oxidative stress wild vegetable