Kim, Kyoung-Ran Lee, Taemin Kim, Byeong-Su Ahn, Dae-Ro 2024-01-20T10:03:28Z 2024-01-20T10:03:28Z 2021-09-04 2014-04 2041-6520 https://pubs.kist.re.kr/handle/201004/126967 DNA nanoconstructs are a potential drug carrier with high biocompatibility. They are promising particularly when therapeutic nucleic acids are the cargos to be delivered, since both the carrier and the cargo are nucleic acids which can be designed, synthesized and assembled in a seamless feature without using post-synthetic conjugation chemistry. However, the unwanted base-paring events between the cargo and the carrier may potentially disturb the desired structure of the cargo-loaded carrier. To address this concern, we propose a DNA nanocarrier composed of L-DNA strands having a bioorthogonal base-paring system. The study presented here provides useful properties of L-DNA as a backbone for the DNA nanocarrier and demonstrates superiority of L-DNA over the natural D-DNA backbone in the delivery of an anti-proliferative aptamer as well as in the construction of the cargo-carrier assembly. English ROYAL SOC CHEMISTRY ENZYMATIC INCORPORATION DRUG-RESISTANCE SIRNA DELIVERY RNA NANOSTRUCTURES CANCER OLIGONUCLEOTIDES NANOPARTICLES TETRAHEDRON CARRIER Utilizing the bioorthogonal base-pairing system of L-DNA to design ideal DNA nanocarriers for enhanced delivery of nucleic acid cargos Article 10.1039/c3sc52601a 1 CHEMICAL SCIENCE, v.5, no.4, pp.1533 - 1537 CHEMICAL SCIENCE 5 4 1533 1537 scie scopus 000332467400034 2-s2.0-84897696077 Chemistry, Multidisciplinary Chemistry Article ENZYMATIC INCORPORATION DRUG-RESISTANCE SIRNA DELIVERY RNA NANOSTRUCTURES CANCER OLIGONUCLEOTIDES NANOPARTICLES TETRAHEDRON CARRIER L-DNA DNA tetrahedron aptamer cellular uptake