Kang, Ki Sung Lee, Woojung Jung, Yujung Lee, Ji Hwan Lee, Seungyong Eom, Dae-Woon Jeon, Youngsic Yoo, Hye Hyun Jin, Ming Ji Song, Kyung Il Kim, Won Jun Ham, Jungyeob Kim, Hyoung Ja Kim, Su-Nam 2024-01-20T10:04:18Z 2024-01-20T10:04:18Z 2021-09-04 2014-03-05 0021-8561 https://pubs.kist.re.kr/handle/201004/127007 The present study investigated the presence and mechanism of esculin-mediated renoprotection to assess its therapeutic potential. Esculin was orally administered at 20 mg/kg/day for 2 weeks to streptozotocin-induced diabetic mice, and its effects were compared with those of the vehicle in normal and diabetic mice. After oral administration of esculin to mice, the concentrations of esculin and esculetin in blood were 159.5 +/- 29.8 and 9.7 +/- 4.9 ng/mL at 30 min, respectively. Food and water intake were significantly increased in the diabetic mice compared to normal mice but attenuated in mice receiving esculin. The elevated blood glucose level and hepatic glucose-6-phosphatase expression were significantly reduced in esculin-treated diabetic mice, supporting the antidiabetic effect of esculin. Esculin also increased the uptake of glucose and induced the insulin-evoked phosphorylation of insulin receptor, Akt, and glycogen synthase kinase 3 beta in C2C12 myotubes, indicating a potential for improvement of insulin sensitivity. In addition, esculin lessened the elevated blood creatinine levels in diabetic mice and ameliorated diabetes-induced renal dysfunction by reducing caspase-3 activation in the kidney. Data support the beneficial effect of esculin against diabetes and oxidative stress-related inflammatory processes in the kidney. English AMER CHEMICAL SOC OXIDATIVE STRESS NEPHROPATHY ESCULETIN APOPTOSIS CELLS MODEL COMPLICATIONS INDUCTION COUMARINS Protective Effect of Esculin on Streptozotocin-Induced Diabetic Renal Damage in Mice Article 10.1021/jf403840c 1 JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY, v.62, no.9, pp.2069 - 2076 JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY 62 9 2069 2076 scie scopus 000332684600007 2-s2.0-84897688603 Agriculture, Multidisciplinary Chemistry, Applied Food Science & Technology Agriculture Chemistry Food Science & Technology Article OXIDATIVE STRESS NEPHROPATHY ESCULETIN APOPTOSIS CELLS MODEL COMPLICATIONS INDUCTION COUMARINS ash bark esculin diabetes renal damage caspase-3