Yu, Myeong S. Jung, Na R. Choi, Kyoung H. Choi, Kuiwon Lee, Bong-Jae Chung, Yoo-Sam 2024-01-20T10:04:31Z 2024-01-20T10:04:31Z 2022-01-25 2014-03 0023-852X https://pubs.kist.re.kr/handle/201004/127017 Objectives/HypothesisAn animal model of obstructive sleep apnea (OSA) may help to investigate the pathophysiology of this disorder and develop appropriate treatments. We investigated the feasibility of a rabbit model of OSA. Study DesignAnimal study. MethodsTwelve New Zealand white rabbits were injected at the base of their tongues under endoscopic guidance with liquid silicone (experimental group, n=6) or normal saline (control group, n=6). Polysomnography was performed before and after injection. The development of OSA and changes in sleep parameters were compared between the two groups. ResultsBefore injection, all rabbits showed normal breathing during sleep without hypopnea. In the silicone group, the rabbits had a mean of 29.96.9 hypopneas/hour and a mean of 10.43.1 apneas/hour 1 month after silicone injection and 28.4 +/- 6.9 hypopneas/hour and 10.0 +/- 3.3 apneas/hour 3 months after silicone injection (P<0.05). Mean total sleep time decreased from 260.3 +/- 70.2 minutes at baseline to 152.5 +/- 38.8 minutes 1 month and 206.8 +/- 60.3 minutes 3 months after injection, with a decrease in stage II sleep. In the saline group, however, there were no breathing events during sleep. ConclusionsThese results show that silicone injections into the tongue base of rabbits can result in OSA. Level of EvidenceN/A Laryngoscope, 124:789-796, 2014 English WILEY-BLACKWELL An Animal Model of Obstructive Sleep Apnea in Rabbit Article 10.1002/lary.24398 1 LARYNGOSCOPE, v.124, no.3, pp.789 - 796 LARYNGOSCOPE 124 3 789 796 N scie scopus 000331374300046 2-s2.0-84894421374 Medicine, Research & Experimental Otorhinolaryngology Research & Experimental Medicine Otorhinolaryngology Article PATHOGENESIS PRESSURE OXIMETRY PIGS Rabbit animal model obstructive sleep apnea sleep