Park, Ji Won Ku, Sook Hee Moon, Hyung-Ho Lee, Minhyung Choi, Donghoon Yang, Jaemoon Huh, Yong-Min Jeong, Ji Hoon Park, Tae Gwan Mok, Hyejung Kim, Sun Hwa 2024-01-20T10:04:40Z 2024-01-20T10:04:40Z 2022-01-10 2014-03 1616-5187 https://pubs.kist.re.kr/handle/201004/127024 Poly(ethylene glycol)-coated cross-linked iron oxide nanoparticles (PCIONs) are developed for therapeutic engineering of mesenchymal stem cells (MSCs) and their monitoring via magnetic resonance (MR) imaging at a time. PCIONs successfully combine with plasmid DNA (pDNA) via ionic interaction. Accordingly, PCION/pDNA complexes mediate superior translocations of vascular endothelial growth factor (VEGF) pDNA into intracellular regions of MSCs under external magnetic field, which significantly elevate production of VEGF from MSCs. Genetically engineered MSCs are also clearly visualized via MR imaging after administration to rat cerebrovascular ischemia models, which enable tracking of MSCs migration from injected sites to injured ischemic area. English WILEY-V C H VERLAG GMBH DELIVERY STROKE TRANSPLANTATION ANGIOGENESIS TRANSFECTION ADULT Cross-linked Iron Oxide Nanoparticles for Therapeutic Engineering and in Vivo Monitoring of Mesenchymal Stem Cells in Cerebral Ischemia Model Article 10.1002/mabi.201300340 1 MACROMOLECULAR BIOSCIENCE, v.14, no.3, pp.380 - 389 MACROMOLECULAR BIOSCIENCE 14 3 380 389 scie scopus 000332932200010 2-s2.0-84896351984 Biochemistry & Molecular Biology Materials Science, Biomaterials Polymer Science Biochemistry & Molecular Biology Materials Science Polymer Science Article DELIVERY STROKE TRANSPLANTATION ANGIOGENESIS TRANSFECTION ADULT cell engineering cerebral ischemia model cross-linked iron oxide nanoparticles magnetic resonance imaging mesenchymal stem cells