Ryu, In Sun Kim, Jae Seung Roh, Jong-Lyel Cho, Kyung-Ja Choi, Seung-Ho Nam, Soon Yuhl Kim, Sang Yoon 2024-01-20T10:30:15Z 2024-01-20T10:30:15Z 2021-09-05 2014-03 1619-7070 https://pubs.kist.re.kr/handle/201004/127048 Purpose Metabolic tumour volume (MTV) and total lesion glycolysis (TLG) from F-18-FDG PET/CT are emerging prognostic biomarkers in human solid cancers; yet few studies have investigated their clinical and prognostic significance in oral cavity squamous cell carcinoma (OSCC). The present retrospective study evaluated the utility of pretreatment MTV and TLG measured by F-18-FDG PET/CT to predict survival and occult metastasis (OM) in OSCC. Methods Of 162 patients with OSCC evaluated preoperatively by F-18-FDG PET/CT, 105 who underwent definitive surgery with or without adjuvant therapy were eligible. Maximum standardized uptake value (SUVmax), MTV and TLG were measured. For calculation of MTV, 3-D regions of interest were drawn and a SUV threshold of 2.5 was used for defining regions. Univariate and multivariate analyses identified clinicopathological and imaging variables associated with OM, disease-free survival (DFS) and overall survival (OS). Results The median (range) SUVmax, MTV and TLG were 7.3 (0.7-41.9), 4.5 ml (0.7-115.1 ml) and 18.3 g (2.4-224.1 g), respectively. Of 53 patients with clinically negative lymph nodes, OM was detected in 19 (36 %). By univariate and multivariate analyses, MTV (P = 0.018) and TLG (P = 0.011) were both independent predictive factors for OM, although they were not independent of each other. The 4-year DFS and OS rates were 53.0 % and 62.0 %, respectively. Univariate and multivariate analyses revealed that MTV (P = 0.001) and TLG (P = 0.006), with different cut-off levels, were both independent predictive factors for DFS, although they were not independent of each other, and MTV (P = 0.001), TLG (P = 0.002) and the involved resection margin (P = 0.007) were independent predictive factors for OS. Conclusion Pretreatment MTV and TLG may be useful in stratifying the likelihood of survival and predicting OM in OSCC. English SPRINGER STANDARDIZED UPTAKE VALUE POSITRON-EMISSION-TOMOGRAPHY NECK-CANCER LUNG-CANCER HEAD RADIOTHERAPY TONGUE CHEMOTHERAPY MANAGEMENT PROLIFERATION Prognostic significance of preoperative metabolic tumour volume and total lesion glycolysis measured by F-18-FDG PET/CT in squamous cell carcinoma of the oral cavity Article 10.1007/s00259-013-2571-z 1 EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING, v.41, no.3, pp.452 - 461 EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING 41 3 452 461 scie scopus 000330966600007 2-s2.0-84894048630 Radiology, Nuclear Medicine & Medical Imaging Radiology, Nuclear Medicine & Medical Imaging Article STANDARDIZED UPTAKE VALUE POSITRON-EMISSION-TOMOGRAPHY NECK-CANCER LUNG-CANCER HEAD RADIOTHERAPY TONGUE CHEMOTHERAPY MANAGEMENT PROLIFERATION Oral cavity cancer F-18-FDG PET/CT Metabolic tumour volume Total lesion glycolysis Prognosis