Song, Myeongjin Jang, Hwanseok Lee, Jaeyeon Kim, Ji Hyun Kim, Soo Hyun Sun, Kyung Park, Yongdoo 2024-01-20T10:30:28Z 2024-01-20T10:30:28Z 2021-09-04 2014-03 0142-9612 https://pubs.kist.re.kr/handle/201004/127059 Regeneration of chronic myocardial infarction (CMI) is one of the challenging issues due to its limited regeneration activity compared to acute or sub-acute stage. In this study, we examined whether combination of stem cell homing factor (SDF-1) and angiogenic peptides (Ac-SDKP) injected with biomimetic hydrogels promote regeneration of cardiac function in a CMI model. We evaluated the regeneration of chronically infarcted myocardium using injectable biomimetic hydrogels containing two therapeutic factors; stromal-derived factor-1 (SDF-1) and Ac-SDKP for stem cell homing and angiogenesis, respectively. Injection of the two therapeutic factors into the infarct region of the left ventricle showed that the biomimetic hydrogels containing two therapeutic factor exhibited significantly improved left ventricle function, increased angiogenesis, decreased infarct size and greatest wall thickness within the infarct region at 4 weeks post-treatment. From these results, it is clear that hydrogels containing two therapeutic factors showed synergistic effects on regeneration in the chronic heart failure model. In conclusion, these results suggest that combination of stem cell homing factor with angiogenic peptides recruit stem cells to the microenvironments, increase the expression of angiogenic genes, enhance the matured vessel formation and improve the cardiac function in chronic MI. (C) 2013 Elsevier Ltd. All rights reserved. English ELSEVIER SCI LTD CHRONIC HEART-FAILURE CORONARY-ARTERY-DISEASE ISCHEMIA/REPERFUSION INJURY SDF-1/CXCR4 AXIS PROGENITOR CELLS CARDIAC-FUNCTION THERAPY REPAIR MODEL EXPRESSION Regeneration of chronic myocardial infarction by injectable hydrogels containing stem cell homing factor SDF-1 and angiogenic peptide Ac-SDKP Article 10.1016/j.biomaterials.2013.12.011 1 BIOMATERIALS, v.35, no.8, pp.2436 - 2445 BIOMATERIALS 35 8 2436 2445 scie scopus 000331679200005 2-s2.0-84891738341 Engineering, Biomedical Materials Science, Biomaterials Engineering Materials Science Article CHRONIC HEART-FAILURE CORONARY-ARTERY-DISEASE ISCHEMIA/REPERFUSION INJURY SDF-1/CXCR4 AXIS PROGENITOR CELLS CARDIAC-FUNCTION THERAPY REPAIR MODEL EXPRESSION SDF-1 Ac-SDKP Matrix metalloproteinase (MMP) Controlled release system Hydrogel Chronic heart failure